NRF2 (Mouse) Transcription Factor Activity Assay Kit


Home / Products / Assay Kits / Activity Kits / NRF2 (Mouse) Transcription Factor Activity Assay Kit

NRF2 (Mouse) Transcription Factor Activity Assay Kit

NRF2 Related Products

Price Inquiry

Welcome! For price inquiries, please feel free to contact us through the form below. We will get back to you as soon as possible.

Cat.No. : Kit-2290
Product Overview : Cellular oxidative and electrophilic stress caused by drugs and other xenobiotics, inflammation, and ionizing radiation are associated with an accumulation of reactive oxygen species and electrophilic insults, which contribute to the pathogenesis of various diseases such as cancer, neurodegenerative disease, and atherosclerosis. In order to protect cells from reactive oxygen species and electrophilic insults, the endogenous cellular antioxidant defense system initiates a response to cellular oxidative and electrophilic stress. NRF2 (nuclear factor (erythroid-derived 2)-like 2; NFE2L2) is a key transcriptional factor regulating hundreds of antioxidant and Phase II detoxification genes. Under normal conditions, NRF2 is sequestered in the cytoplasm through binding with Keap1, an actin-binding protein and finally is degraded through the Keap1-dependent ubiquitination. In response to a stimulus, degradation of Keap1 is markedly increased. This leads to the disruption of the Keap1-NRF2 complex and nuclear translocation of NRF2. NRF2 then dimerizes with small Maf proteins and binds to the ARE (antioxidative response element) in promoters of downstream genes to initiate expression. Accurate monitoring of the level of activated NRF2 in cells, tissues or animal models is required for investigating signal transduction pathways and other research applications such as drug development. Simple, speedy and high-throughput methods are required for this purpose. The NRF2 Transcription Factor-Activity Assay kit is a non-radioactive transcription factor assay with an ELISA format. It offers an easy, speedy, sensitive and high-throughput method to detect the activation of transcription factors.
Applications : Detecting the NRF2 in mouse nuclear extraction and whole lysates.
Storage : -20°C
Size : 100 assays

Online Inquiry

  • Note: There will be extra charge for optional service!
  • Verification Code Please review Creative BioMart's privacy policy for more information

Optional Service: Optional requirements on this protein

Other Requirements:

Apply For A Coupon

$50 OFF Your First Purchase

Apply For a Coupon

Enter your email here to subscribe.

creative biomart inc.

Easy access to products and services you need from our library via powerful searching tools.

Follow Us

Copyright © 2007 – 2021 Creative BioMart. All Rights Reserved. Terms and Conditions | Privacy Policy