Purmorphamine, GMP Grade

• Cat.No.: Purmorphamine-13
• Product Overview: Purmorphamine (GMP) is Purmorphamine produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture.

Specification

• Description: Purmorphamine is a smoothened/Smo receptor agonist with an EC50 of 1 μM
• Form: Solid, Off-white to pale purple
• Target: Smo
• In Vitro: Purmorphamine (GMP) (1.5 μM, 1 week) can generate embryoid bodies (EBs) from human iPS cells (hiPS2) and hESCs (HSF1). Purmorphamine (GMP) (1.5 μM) converts hPSCs to NKX2-1 positive MGE cells. Purmorphamine (GMP) (2 μM, day 28-35) promotes ventralization of the brain spheroids in differentiation process from hiPSCs. Purmorphamine (GMP) (1 μM) together with retinoic acid (RA, 2 μM) promotes hiPSC differentiation into functional neural tissue, indicated by the expression of neuronal marker β-tubulin III (βT-III). Purmorphamine (GMP) (day5-7) induces hESCs differentiation into dopaminergic (DA) neurons.
• CAS: 483367-10-8
• Formula: C31H32N6O2
• Molecular Mass: 520.62

Gene Information

• Pathway: Stem Cell/Wnt
• Synonyms: Purmorphamine