Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

Rabbit Anti-Mouse Interleukin-11 Receptor Alpha Chain Monoclonal Antibody

Cat.No. : CAB11560RM
Product Overview : Rabbit Monoclonal Antibody to Mouse Interleukin-11 Receptor Alpha Chain
  • Specification
  • Gene Information
  • Related Products
Antigen Description : Mouse interleukin-11 receptor alpha chain, also known as IL-11R-alpha, and IL11RA, is a single-pass type Imembrane protein. It belongs to the type Icytokine receptor family and type 3 subfamily and contains two fibronectin type-III domains and one Ig-like C2-type (immunoglobulin-like) domain. Interleukin 11 receptor is a heterodimer composed of an interleukin 11 receptor alpha subunit and an incompletely characterized beta subunit. IL11RA is expressed in a number of cell lines, including the myelogenous leukemia cell line K562, the megakaryocytic leukemia cell line Mo7E, the erythroleukemia cell line TF1, and the osteosarcoma cell lines, MG-63 and Saos-2. It is also expressed in normal and malignant prostate epithelial cell lines. IL11RA is a receptor for interleukin-11. The receptor systems for IL6, LIF, OSM, CNTF, IL11 and CT1 can utilize IL6ST for initiating signal transmission. The IL11/IL11RA/IL6ST complex may be involved in the control of proliferation and differentiation of skeletogenic progenitor or other mesenchymal cells.
Specificity : Mouse IL11RA / IL11Rα. No cross-reactivity with human cell lysate ( 293 cell line ) in WB and ELISA.
Immunogen : Recombinant mouse IL11RA protein
Host : Rabbit
Isotype : Rabbit IgG
Species : Mouse
Cross Reactivity : 025
Clone : A026
Applications : WB; ELISA
Dilution : Western blot: This antibody can be used at 1 - 2 μg/mL with the appropriate secondary reagents to detect mouse IL11RA in WB. Using a DAB detection system, the detection limit for mouse IL11RA is approximately 0.25 ng/lane under non-reducing conditions and reducing conditionsDirect ELISA: This antibody can be used at 0.1 - 0.2 μg/mL with the appropriate secondary reagents to detect mouse IL11RA. The detection limit for mouse IL11RA is approximately 0.00245 ng/well
Preparation : This antibody was obtained from a rabbit immunized with purified, human cell-derived, recombinant mouse IL11RA ( rM IL11RA ; NP_001156873.1 ; Met 1 - Gln 367 )
Format : 0.2 μm filtered solution in PBS with 5% trehalose
Storage : This antibody can be stored at 2-8 °C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 to -70 °C. Preservative-Free.Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Gene Name : Il11ra1 interleukin 11 receptor, alpha chain 1 [ Mus musculus ]
Official Symbol : Il11ra1
Synonyms : IL11RA1; interleukin 11 receptor, alpha chain 1; interleukin-11 receptor subunit alpha-1; NR-1; etl-2; locus 2; IL-11RA1; Il-11ra-alpha; IL-11R-alpha-1; IL-11R subunit alpha-1; novel cytokine receptor 1; enhancer trap locus homolog 2; IL-11 receptor subunit alpha-1; interleukin 11 receptor, alpha chain 2; NR1; GP130; Il11ra; Il-11ra; Il11ra2; AI314697;
Gene ID : 16157
mRNA Refseq : NM_001163401
Protein Refseq : NP_001156873
Pathway : Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Hematopoietic cell lineage, organism-specific biosystem; Hematopoietic cell lineage, conserved biosystem; Jak-STAT signaling pathway, organism-specific biosystem; Jak-STAT signaling pathway, conserved biosystem;
Function : cytokine receptor activity; interleukin-11 binding; interleukin-11 receptor activity; receptor activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

Inquiry

  • Q&As
  • Reviews

Q&As (10)

Ask a question
What are the advanced imaging techniques used to visualize the dynamic conformational changes of IL11RA1 upon ligand binding? 07/04/2022

Advanced imaging techniques visualize IL11RA1 conformational changes upon ligand binding.

Can you elaborate on the utilization of animal models and transgenic approaches to study the tissue-specific functions of IL11RA1? 04/15/2022

Animal models and transgenics study IL11RA1's tissue-specific functions.

How do reporter gene assays help in studying the transcriptional regulation of IL11RA1 gene expression? 02/28/2022

Reporter gene assays study IL11RA1 gene expression regulation.

Can you explain the role of high-throughput screening in identifying small molecules that modulate IL11RA1 activity? 10/02/2021

High-throughput screening identifies small molecules modulating IL11RA1 activity.

What insights have functional genomics studies provided regarding the role of IL11RA1 in disease pathogenesis? 09/22/2020

Functional genomics unveil IL11RA1's role in disease pathogenesis.

How does site-directed mutagenesis contribute to understanding the binding interface between IL11RA1 and IL11? 07/09/2020

Site-directed mutagenesis reveals the binding interface of IL11RA1 and IL11.

What methodologies like fluorescence resonance energy transfer (FRET) elucidate the intracellular signaling pathways activated by IL11RA1? 01/07/2020

Fluorescence resonance energy transfer (FRET) reveals IL11RA1 signaling pathways.

How are biophysical methods such as circular dichroism (CD) spectroscopy employed to investigate the secondary structure changes of IL11RA1? 01/26/2019

Circular dichroism (CD) spectroscopy probes IL11RA1 secondary structure changes.

How do proteomic analyses contribute to identifying IL11RA1-interacting proteins and potential signaling complexes? 09/18/2018

Proteomics identifies IL11RA1-interacting proteins and signaling complexes.

What strategies like surface plasmon resonance (SPR) aid in quantifying the binding kinetics between IL11RA1 and its downstream effectors? 01/02/2017

Surface plasmon resonance (SPR) quantifies IL11RA1 binding kinetics.

Customer Reviews (3)

Write a review
Reviews
08/14/2021

    Good for cytokine assays.

    02/01/2021

      Effective in signaling studies.

      01/09/2019

        Consistent bioactivity.

        Ask a Question for All Il11ra1 Products

        Required fields are marked with *

        My Review for All Il11ra1 Products

        Required fields are marked with *

        0

        Inquiry Basket

        cartIcon
        logo

        FOLLOW US

        Terms and Conditions        Privacy Policy

        Copyright © 2024 Creative BioMart. All Rights Reserved.

        Contact Us

        • /

        Stay Updated on the Latest Bioscience Trends