| Cat.No. : |
CAB11560RM
Optional Service: Optional requirements on this protein
|
| Product Overview : |
Rabbit Monoclonal Antibody to Mouse Interleukin-11 Receptor Alpha Chain |
| Antigen Description : |
Mouse interleukin-11 receptor alpha chain, also known as IL-11R-alpha, and IL11RA, is a single-pass type Imembrane protein. It belongs to the type Icytokine receptor family and type 3 subfamily and contains two fibronectin type-III domains and one Ig-like C2-type (immunoglobulin-like) domain. Interleukin 11 receptor is a heterodimer composed of an interleukin 11 receptor alpha subunit and an incompletely characterized beta subunit. IL11RA is expressed in a number of cell lines, including the myelogenous leukemia cell line K562, the megakaryocytic leukemia cell line Mo7E, the erythroleukemia cell line TF1, and the osteosarcoma cell lines, MG-63 and Saos-2. It is also expressed in normal and malignant prostate epithelial cell lines. IL11RA is a receptor for interleukin-11. The receptor systems for IL6, LIF, OSM, CNTF, IL11 and CT1 can utilize IL6ST for initiating signal transmission. The IL11/IL11RA/IL6ST complex may be involved in the control of proliferation and differentiation of skeletogenic progenitor or other mesenchymal cells. |
| Specificity : |
Mouse IL11RA / IL11Rα. No cross-reactivity with human cell lysate ( 293 cell line ) in WB and ELISA. |
| Immunogen : |
Recombinant mouse IL11RA protein |
| Host : |
Rabbit |
| Isotype : |
Rabbit IgG |
| Species : |
Mouse |
| Cross Reactivity : |
025 |
| Clone : |
A026 |
| Applications : |
WB; ELISA |
| Dilution : |
Western blot: This antibody can be used at 1 - 2 μg/mL with the appropriate secondary reagents to detect mouse IL11RA in WB. Using a DAB detection system, the detection limit for mouse IL11RA is approximately 0.25 ng/lane under non-reducing conditions and reducing conditionsDirect ELISA: This antibody can be used at 0.1 - 0.2 μg/mL with the appropriate secondary reagents to detect mouse IL11RA. The detection limit for mouse IL11RA is approximately 0.00245 ng/well |
| Preparation : |
This antibody was obtained from a rabbit immunized with purified, human cell-derived, recombinant mouse IL11RA ( rM IL11RA ; NP_001156873.1 ; Met 1 - Gln 367 ) |
| Format : |
0.2 μm filtered solution in PBS with 5% trehalose |
| Storage : |
This antibody can be stored at 2-8 °C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 to -70 °C. Preservative-Free.Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles. |
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
