Recombinant Active Human ROS1 (L2086F) Protein (1881-end), N-GST-tagged
Cat.No. : | ROS1-24H |
Product Overview : | Recombinant human ROS1 (L2086F) (1881-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. |
- Specification
- Gene Information
- Related Products
Description : | ROS1 is a proto-oncogene and member of the sevenless subfamily of tyrosine kinase insulin receptor genes. ROS1 is highly-expressed in a variety of tumor cell lines and functions as a growth or differentiation factor receptor. The FIG gene can fuse with the ROS1 gene in glioblastoma cell lines. The resulting ROS1/FIG fusion protein is a constitutively activated tyrosine kinase. Direct interaction of ROS1 and the phosphatase SHP-1 can lead to efficient downregulation of ROS1-mediated signaling. Binding sites in the ROS1 cytoplasmic domain display high affinity binding to the SHP-1 N-terminal SH2 domain. Structural models of ROS1 (L2086F) predict resistance to crizotinib, entrectinib, and lolartanib via steric hindrance. |
Source : | Sf9 insect cells |
Species : | Human |
Tag : | N-GST |
Bio-activity : | The specific activity of ROS1(L2086F) was determined to be 121 nmol/min/mg as per actity assay protocol. |
Molecular Mass : | Observed MW: ~82 kDa. Calculated MW: ~79 kDa. |
Protein Length : | 1881-end |
Purity : | The purity of ROS1(L2086F) was determined to be > 90 % by densitometry. |
Stability : | One year at -70 centigrade from date of shipment. |
Storage : | Store product at -70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
Concentration : | 0.1 μg/μL |
Storage Buffer : | Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, and 25% glycerol. |
Shipping : | Dry ice |
Gene Name : | ROS1 c-ros oncogene 1, receptor tyrosine kinase [ Homo sapiens (human) ] |
Official Symbol : | ROS1 |
Synonyms : | ROS1; c-ros oncogene 1, receptor tyrosine kinase; v ros avian UR2 sarcoma virus oncogene homolog 1, v ros UR2 sarcoma virus oncogene homolog 1 (avian); proto-oncogene tyrosine-protein kinase ROS; c ros 1; MCF3; ROS; proto-oncogene c-Ros; proto-oncogene c-Ros-1; c-Ros receptor tyrosine kinase; receptor tyrosine kinase c-ros oncogene 1; v-ros UR2 sarcoma virus oncogene homolog 1; transmembrane tyrosine-specific protein kinase; v-ros avian UR2 sarcoma virus oncogene homolog 1; c-ros-1; |
Gene ID : | 6098 |
mRNA Refseq : | NM_002944 |
Protein Refseq : | NP_002935 |
MIM : | 165020 |
UniProt ID : | P08922 |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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