Recombinant Active Human SIGLEC15 Protein (ECD), Fc-His-tagged(C-ter)

• Cat.No.: SIGLEC15-291H
• Product Overview: Recombinant Active Human SIGLEC15 Protein (ECD) with Fc-His tag (C-ter) was expressed in HEK293.

Specification

• Description: Predicted to be involved in regulation of actin cytoskeleton organization; regulation of bone resorption; and regulation of osteoclast development. Predicted to be integral component of membrane. Predicted to be part of protein-containing complex. Predicted to be active in plasma membrane.
• Source: HEK293
• Species: Human
• Tag: Fc-His(C-ter)
• Form: Powder
• Bio-activity: Measured by its ability to inhibit Anti-CD3-induced proliferation of Jurkat cells. The ED50 for this effect is 1.8-7.2 μg/mL.
• Protein Length: Phe20-Thr263
• Endotoxin: Endotoxin level is less than 0.1 EU/μg of the protein, as determined by the LAL test.
• Purity: > 95% (by SDS-PAGE)
• Applications: FuncSt, SDS-PAGE
• Notes: For laboratory research only, not for drug, diagnostic or other use.
• Storage: Lyophilized protein should be stored at -20°C or -80°C. After reconstitution, aliquot and store at -20°C for up to one month, at 2-8°C for up to one week. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening.
• Storage Buffer: PBS (pH 7.4) and 300 mM NaCl.
• Reconstitution: Reconstitute to a concentration of 0.1-0.5 mg/ml in sterile distilled water.

Gene Information

• Gene Name: SIGLEC15 sialic acid binding Ig like lectin 15 [ Homo sapiens (human) ]
• Official Symbol: SIGLEC15
• Synonyms: SIGLEC15; sialic acid binding Ig like lectin 15; CD33L3; HsT1361; SIGLEC-15; sialic acid-binding Ig-like lectin 15; CD33 antigen-like 3; CD33 molecule-like 3
• Gene ID: 284266
• mRNA Refseq: NM_213602
• Protein Refseq: NP_998767
• MIM: 618105
• UniProt ID: Q6ZMC9