Recombinant COVID-19 Envelope protein, His-tagged

• Cat.No.: E-137V
• Product Overview: Recombinant COVID-19 Envelope protein(Met1-Val75), fused to BBP, 6*His-tag at the N-terminus, was expressed in E.coli and purified by affinity purification chromatography.

Specification

• Description: Coronavirus envelope (E) proteins are short (100 residues) polypeptides that contain at least one transmembrane (TM) domain and a cluster of 2-3 juxtamembrane cysteines. These proteins are involved in viral morphogenesis and tropism, and their absence leads in some cases to aberrant virions, or to viral attenuation. In common to other viroporins, coronavirus envelope proteins increase membrane permeability to ions, plays a central role in virus morphogenesis and assembly. Acts as a viroporin and self-assembles in host membranes forming pentameric protein-lipid pores that allow ion transport. Also plays a role in the induction of apoptosis. Activates the host NLRP3 inflammasome, leading to IL-1beta overproduction.
• Source: E.coli
• Species: COVID-19
• Tag: His
• Form: Supplied as a 0.2 μM filtered solution of 20mM Tris-HCl, 200mM NaCl, pH 8.0.
• Molecular Mass: Mol Mass: 27.5 kDa; AP Mol Mass: 22-25 kDa, reducing conditions.
• Protein length: Met1-Val75
• Purity: Greater than 85% as determined by reducing SDS-PAGE.
• Applications: Immunogen, calibrator or standard.
• Storage: Reconstituted protein solution should be stored at ≤ -20 centigrade.
• Shipping: The product is shipped on dry ice pack. Upon receipt, store it immediately at the temperature listed below.
• Warning: FOR RESEARCH OR FURTHER MANUFACTURING USE ONLY

Gene Information

• Gene Name: E
• Official Symbol: E
• Synonyms: GU280_gp04
• Gene ID: 43740570
• Protein Refseq: YP_009724392.1