Recombinant COVID-19 NSP1 protein, His-tagged NSP1-002V

Recombinant COVID-19 NSP1 protein, His-tagged

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Recombinant COVID-19 NSP1 protein, His-tagged

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Cat.No. : NSP1-002V
Product Overview : Recombinant COVID-19 NSP1 protein (Met1-Gly180) was fused to his-tag at the C-terminus and expressed in E.coli.
Description : The viral nonstructural protein 1 (nsP1) is the only membrane-associated protein that anchors the replication complex to the cellular membranes. NSP1 inhibits host translation by interacting with the 40S ribosomal subunit. The nsp1-40S ribosome complex further induces an endonucleolytic cleavage near the 5'UTR of host mRNAs, targeting them for degradation. Viral mRNAs are not susceptible to nsp1-mediated endonucleolytic RNA cleavage thanks to the presence of a 5'-end leader sequence and are therefore protected from degradation. By suppressing host gene expression, nsp1 facilitates efficient viral gene expression in infected cells and evasion from host immune response.
Source : E.coli
Species : COVID-19
Tag : His
Predicted N Terminal : Met
Form : Lyophilized from 0.22 μm filtered solution in PBS, Arginine, pH7.4, 10% trehalose.
Molecular Mass : The protein has a calculated MW of 21.7 kDa. The protein migrates as 22-25 kDa under reducing (R) condition (SDS-PAGE).
Protein length : Met1-Gly180
Endotoxin : Less than 1.0 EU per μg by the LAL method.
Purity : >90% as determined by SDS-PAGE.
Storage : For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20 to -70 centigrade for 12 months in lyophilized state;
-70 centigrade for 3 months under sterile conditions after reconstitution.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 mg/ml. Centrifuge the vial at 4°C before opening to recover the entire contents.
Shipping : Powder,RT
SDS-PAGE of NSP1-002V :

COVID-19 NSP1, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.

Gene Name : orf1ab
Official Symbol : orf1ab
Synonyms : pp1ab
Gene ID : 1489680
Protein Refseq : NP_828860.2
UniProt ID : P0C6X7

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