Recombinant COVID-19 Spike protein receptor binding domain (RBD), His-tagged Spike-190V

Recombinant COVID-19 Spike protein receptor binding domain (RBD), His-tagged

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Recombinant COVID-19 Spike protein receptor binding domain (RBD), His-tagged

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Cat.No. : Spike-190V
Product Overview : Recombinant COVID-19 Spike protein receptor binding domain (RBD) was fused to His-tag at C-terminus and expressed in human cells.
Description : The spike (S) glycoprotein of coronaviruses contains protrusions that will only bind to certain receptors on the host cell: they are essential for both host specificity and viral infectivity. The term 'peplomer' is typically used to refer to a grouping of heterologous proteins on the virus surface that function together. The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process. Most notable is severe acute respiratory syndrome (SARS). The severe acute respiratory syndrome-coronavirus (SARS-CoV) spike (S) glycoprotein alone can mediate the membrane fusion required for virus entry and cell fusion. It is also a major immunogen and a target for entry inhibitors. The SARS-CoV spike (S) protein is composed of two subunits; the S1 subunit contains a receptor-binding domain that engages with the host cell receptor angiotensin-converting enzyme 2 and the S2 subunit mediates fusion between the viral and host cell membranes. The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity, during infection with SARS-CoV.
Source : Human Cells
Species : COVID-19
Tag : His
Form : PBS, pH7.4.
Molecular Mass : The recombinant receptor binding domain (RBD) of 2019-nCoV spike consists of 234 amino acids and predicts a molecular mass of 26.5 kDa.
Protein length : 234
Endotoxin : <1.0 EU per μg protein as determined by the LAL method.
Purity : >95% as determined by SDS-PAGE.
Gene Name : Spike
Synonyms : BHT41_gp02
SDS-PAGE of Spike-190V :

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