Recombinant Cynomolgus monkey CD3E Protein, His and Fc-tagged
Cat.No. : | CD3E-140C |
Product Overview : | Recombinant Cynomolgus monkey CD3E protein with His and Fc tag was expressed in HEK293. |
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Description : | The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause immunodeficiency. This gene has also been linked to a susceptibility to type I diabetes in women. |
Source : | HEK293 |
Species : | Cynomolgus monkey |
Tag : | His&Fc |
Form : | Lyophilized |
Molecular Mass : | 38.3 kDa |
Protein length : | 198 |
AA Sequence : | MQSGTRWRVLGLCLLSIGVWGQDGN EEMGSITQTPYQVSISGTTVILTCS QHLGSEAQWQHNGKNKEDSGDRLFL PEFSEMEQSGYYVCYPRGSNPEDAS HHLYLKARVCENCMEMDVMAVATIV IVDICITLGLLLLVYYWSKNRKAKA KPVTRGAGAGGRQRGQNKERPPPVP NPDYEPIRKGQQDLYSGLNQRRI |
Purity : | > 98% |
Applications : | WB; ELISA; FACS; FC |
Stability : | This bioreagent is stable at 4 centigrade (short-term) and -70 centigrade(long-term). After reconstitution, sample may be stored at 4 centigrade for 2-7 days and below -18 centigrade for future use. |
Storage : | At -20 centigrade. |
Concentration : | 1 mg/mL |
Storage Buffer : | PBS (pH 7.4-7.5). Sterile-filtered colorless solution. |
Reconstitution : | Reconstitute in sterile distilled H2O to no less than 100 μg/mL; dilute reconstituted stock further in other aqueous solutions if needed. Please review COA for lot-specific instructions. Final measurements should be determined by the end-user for optimal performance. |
Gene Name : | CD3E CD3e molecule, epsilon (CD3-TCR complex) [ Macaca mulatta (Rhesus monkey) ] |
Official Symbol : | CD3E |
Synonyms : | CD3E; CD3e molecule, epsilon (CD3-TCR complex); T-cell surface glycoprotein CD3 epsilon chain; |
Gene ID : | 699467 |
mRNA Refseq : | XM_015115816 |
Protein Refseq : | XP_014971302 |
UniProt ID : | G7NCB9 |
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CD3E-142H | Recombinant Human CD3E Protein, His and Fc-tagged | +Inquiry |
◆ Lysates | ||
CD3E-1275HCL | Recombinant Human CD3E cell lysate | +Inquiry |
CD3E-1602CCL | Recombinant Cynomolgus CD3E cell lysate | +Inquiry |
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Not For Human Consumption!
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Customer Reviews (3)
Write a reviewManufacturers with the capacity for bulk production can offer CD3E protein in larger quantities, which is advantageous for researchers working on large-scale experiments or collaborations.
bulk production often leads to economies of scale, making the CD3E protein more cost-effective for research budgets.
Manufacturers can actively seek collaborations and partnerships with researchers to develop new applications or optimize methodologies using CD3E protein.
Q&As (5)
Ask a questionYes, CD3E levels and T-cell function can be monitored to evaluate the response to cancer immunotherapies like checkpoint inhibitors.
There are currently no approved therapies that directly target CD3E, but it is a target for research in developing immunotherapies and cancer treatments.
There may be ongoing clinical trials using CD3E-targeted therapies in the context of cancer and autoimmune diseases. It's important to check clinical trial databases for specific studies.
Yes, monitoring CD3E levels in HIV-infected individuals can provide valuable information about the progression of the disease and the effectiveness of antiretroviral therapy.
CD3E can be used in research to study T-cell responses in allergic conditions, helping to better understand and diagnose allergies.
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