Recombinant Mouse CD3E Protein, Fc-tagged
Cat.No. : | CD3E-144M |
Product Overview : | Recombinant Mouse CD3E protein with Fc tag was expressed in HEK293. |
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Description : | Predicted to enable several functions, including SH3 domain binding activity; identical protein binding activity; and protein heterodimerization activity. Involved in nervous system development and positive regulation of cell adhesion. Acts upstream of or within several processes, including positive regulation of T cell activation; positive regulation of cytokine production; and regulation of signal transduction. Located in several cellular components, including dendritic spine; external side of plasma membrane; and immunological synapse. Part of alpha-beta T cell receptor complex. Is expressed in colon and hemolymphoid system. Human ortholog(s) of this gene implicated in immunodeficiency 18. Orthologous to human CD3E (CD3e molecule). |
Source : | HEK293 |
Species : | Mouse |
Tag : | Fc |
Form : | Lyophilized |
Molecular Mass : | 36 kDa |
Protein length : | 189 |
AA Sequence : | MRWNTFWGILCLSLLAVGTCQDDAE NIEYKVSISGTSVELTCPLDSDENL KWEKNGQELPQKHDKHLVLQDFSEV EDSGYYVCYTPASNKNTYLYLKARV CEYCVEVDLTAVAIIIIVDICITLG LLMVIYYWSKNRKAKAKPVTRGTGA GSRPRGQNKERPPPVPNPDYEPIRK GQRDLYSGLNQRAV |
Purity : | > 98% |
Applications : | WB; ELISA; FACS; FC |
Stability : | This bioreagent is stable at 4 centigrade (short-term) and -70 centigrade(long-term). After reconstitution, sample may be stored at 4 centigrade for 2-7 days and below -18 centigrade for future use. |
Storage : | At -20 centigrade. |
Concentration : | 1 mg/mL |
Storage Buffer : | PBS (pH 7.4-7.5). Sterile-filtered colorless solution. |
Reconstitution : | Reconstitute in sterile distilled H2O to no less than 100 μg/mL; dilute reconstituted stock further in other aqueous solutions if needed. Please review COA for lot-specific instructions. Final measurements should be determined by the end-user for optimal performance. |
Gene Name : | Cd3e CD3 antigen, epsilon polypeptide [ Mus musculus (house mouse) ] |
Official Symbol : | CD3E |
Synonyms : | CD3E; CD3 antigen, epsilon polypeptide; T-cell surface glycoprotein CD3 epsilon chain; T-cell surface antigen T3/Leu-4 epsilon chain; CD3; T3e; AI504783; CD3epsilon; |
Gene ID : | 12501 |
mRNA Refseq : | NM_007648 |
Protein Refseq : | NP_031674 |
UniProt ID : | P22646 |
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◆ Lysates | ||
CD3E-1275HCL | Recombinant Human CD3E cell lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Customer Reviews (3)
Write a reviewManufacturers with the capacity for bulk production can offer CD3E protein in larger quantities, which is advantageous for researchers working on large-scale experiments or collaborations.
bulk production often leads to economies of scale, making the CD3E protein more cost-effective for research budgets.
Manufacturers can actively seek collaborations and partnerships with researchers to develop new applications or optimize methodologies using CD3E protein.
Q&As (5)
Ask a questionYes, CD3E levels and T-cell function can be monitored to evaluate the response to cancer immunotherapies like checkpoint inhibitors.
There are currently no approved therapies that directly target CD3E, but it is a target for research in developing immunotherapies and cancer treatments.
There may be ongoing clinical trials using CD3E-targeted therapies in the context of cancer and autoimmune diseases. It's important to check clinical trial databases for specific studies.
Yes, monitoring CD3E levels in HIV-infected individuals can provide valuable information about the progression of the disease and the effectiveness of antiretroviral therapy.
CD3E can be used in research to study T-cell responses in allergic conditions, helping to better understand and diagnose allergies.
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