Recombinant Full Length Bovine Tetraspanin-8(Tspan8) Protein, His-Tagged

• Cat.No.: RFL28123BF
• Product Overview: Recombinant Full Length Bovine Tetraspanin-8(TSPAN8) Protein (Q2KIS9) (1-238aa), fused to N-terminal His tag, was expressed in E. coli.

Specification

• Source: E.coli expression system
• Species: Bos taurus (Bovine)
• Tag: His
• Form: Lyophilized powder
• Protein Length: Full Length (1-238)
• AA Sequence: MAGVNVCIKCSMFIFNFVFWLCGAI ILSVAISIRAGKIGQEILAPGDADL NLFIAVNILI FVGAVIMILGFLGCCGAMKENQFMM ILFFVGLLMILLLQVAAGIVATTRK SKTEQALNKT LLINARLLSSTDENERVFQKAFSEL QEELKCCGLVNGASDWGSNFQHYYR TCECPSESDS SCTKYSGKTIYKQSCFASISQMFSK RLFIVLALAFGLAAIEVLGLIFSIV LYCQMRKK
• Purity: Greater than 90% as determined by SDS-PAGE.
• Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
• Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
• Storage Buffer: Tris/PBS-based buffer, 6% Trehalose, pH 8.0
• Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
• Gene Name: TSPAN8
• Synonyms: TSPAN8; Tetraspanin-8; Tspan-8
• UniProt ID: Q2KIS9

Gene Information

• Gene Name: TSPAN8
• Synonyms: TSPAN8; Tetraspanin-8; Tspan-8
• UniProt ID: Q2KIS9

Reviews

04/30/2022

Due to wide range of applications of TSPAN8 is impressive, and no matter what field, it can play an important role.

11/06/2020

Band position of TSPAN8 in Western blot was consistent with the expected, showing good target recognition ability.

06/29/2019

The stability of TSPAN8 is excellent, and its performance remains stable after many repeated uses, showing good product quality.

Q&As

What is the significance of TSPAN8 protein in disease diagnosis and prognosis?

Detecting the expression level of TSPAN8 protein can help with the diagnosis and prognosis of certain diseases. For example, in colon cancer patients, high expression of the TSPAN8 protein is often associated with malignancy and poor prognosis of the tumor.

What is the role of the interaction of the TSPAN8 protein with other proteins in the disease?

The interaction of the TSPAN8 protein with other proteins plays an important role in a variety of diseases. For example, in colon cancer, the TSPAN8 protein can interact with integrins, promoting the proliferation and migration of tumor cells. Therefore, understanding these interactions is important for understanding the pathogenesis of disease and the selection of therapeutic targets.

What are the possible applications of TSPAN8 protein in future medical and scientific research?

With the in-depth understanding of the structure and function of TSPAN8 protein, the drug development and application of TSPAN8 protein will be more extensive in the future. For example, the development of drugs targeting the TSPAN8 protein may be used to treat tumors, autoimmune diseases, and neurological diseases.

Are there polymorphisms in the TSPAN8 gene, and are these polymorphisms associated with disease?

There are a variety of polymorphisms in the TSPAN8 gene that may affect the structure and function of proteins and are associated with the development of certain diseases. For example, one study found that a polymorphism in the TSPAN8 gene was associated with susceptibility to esophageal cancer in northern Chinese populations.

Is TSPAN8 protein involved in apoptosis?

Studies have shown that the TSPAN8 protein can participate in the apoptosis process. It can regulate the permeability of mitochondrial membranes by interacting with members of the Bcl-2 family, thereby influencing the conduction of apoptosis signals.

How is the activity of TSPAN8 protein regulated?

The activity of TSPAN8 protein is affected by a variety of regulators, including phosphorylation modification, ubiquitination modification, etc. These regulators can influence the structure and function of the TSPAN8 protein and thus its biological function.