Recombinant Full Length Human ACVR1 Protein, C-Flag-tagged

• Cat.No.: ACVR1-1452HFL
• Product Overview: Recombinant Full Length Human ACVR1 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors. Mutations in this gene are associated with fibrodysplasia ossificans progressive.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 55 kDa
• AA Sequence: MVDGVMILPVLIMIALPSPSMEDEK PKVNPKLYMCVCEGLSCGNEDHCEG QQCFSSLSINDGFHVYQKGC FQVYEQGKMTCKTPPSPGQAVECCQ GDWCNRNITAQLPTKGKSFPGTQNF HLEVGLIILSVVFAVCLLAC LLGVALRKFKRRNQERLNPRDVEYG TIEGLITTNVGDSTLADLLDHSCTS GSGSGLPFLVQRTVARQITL LECVGKGRYGEVWRGSWQGENVAVK IFSSRDEKSWFRETELYNTVMLRHE NILGFIASDMTSRHSSTQLW LITHYHEMGSLYDYLQLTTLDTVSC LRIVLSIASGLAHLHIEIFGTQGKP AIAHRDLKSKNILVKKNGQC CIADLGLAVMHSQSTNQLDVGNNPR VGTKRYMAPEVLDETIQVDCFDSYK RVDIWAFGLVLWEVARRMVS NGIVEDYKPPFYDVVPNDPSFEDMR KVVCVDQQRPNIPNRWFSDPTLTSL AKLMKECWYQNPSARLTALR
  IKKTLTKIDNSLDKLKTDCTRTRPL EQKLISEEDLAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome, ES Cell Differentiation/IPS, Protein Kinase, Transmembrane
• Protein Pathways: Cytokine-cytokine receptor interaction, TGF-beta signaling pathway

Gene Information

• Gene Name: ACVR1 activin A receptor type 1 [ Homo sapiens (human) ]
• Official Symbol: ACVR1
• Synonyms: FOP; ALK2; SKR1; TSRI; ACTRI; ACVR1A; ACVRLK2
• Gene ID: 90
• mRNA Refseq: NM_001105.5
• Protein Refseq: NP_001096.1
• MIM: 102576
• UniProt ID: Q04771