Recombinant Full Length Human ADAR Protein, His&GST tagged

• Cat.No.: ADAR-21H
• Product Overview: Recombinant full-length human ADAR1 (p110) was expressed by baculovirus in Sf9 insect cells using an N-terminal His-GST tag

Specification

• Species: Human
• Source: Sf9 Cells
• Tag: GST&His
• Protein Length: 1-1226 aa
• Description: This gene encodes the enzyme responsible for RNA editing by site-specific deamination of adenosines. This enzyme destabilizes double-stranded RNA through conversion of adenosine to inosine. Mutations in this gene have been associated with dyschromatosis symmetrica hereditaria. Alternative splicing results in multiple transcript variants.
• Purity: >70%
• Stability: 1 year at –70 centigrade from date of shipment.
• Storage: Store product at –70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
• Storage Buffer: Recombinant protein stored 50mM sodium phosphate, pH 7.0, 300mM NaCl, 150mM imidazole, 0.25mM DTT, 25% glycerol.
• Concentration: 0.09 μg/μL
• Shipping: Dry ice
• Reference: 1. Song, B. et al.: The role of RNA editing enzyme ADAR1 in human disease. WIRES RNA. 2022;13(1):e1665. 2. Shiromoto, S. M. et al.: Y. ADAR1 controls apoptosis of stressed cells by inhibiting Staufen1-mediated mRNA decay. Nature Structural and Molecular Biology. 2017; 24(6), 534–543

Gene Information

• Gene Name: ADAR adenosine deaminase RNA specific [ Homo sapiens (human) ]
• Official Symbol: ADAR
• Synonyms: ADAR; adenosine deaminase RNA specific; DSH; AGS6; G1P1; IFI4; P136; ADAR1; DRADA; DSRAD; IFI-4; K88DSRBP
• Gene ID: 103
• mRNA Refseq: NM_001025107
• Protein Refseq: NP_001020278
• MIM: 146920
• UniProt ID: Q9BYM4