Recombinant Full Length Human ADGRF3 Protein

• Cat.No.: ADGRF3-5569HF
• Product Overview: Human GPR113 full-length ORF (AAI52989.1) recombinant protein without tag.

Specification

• Description: ADGRF3 (Adhesion G Protein-Coupled Receptor F3) is a Protein Coding gene
• Source: In Vitro Cell Free System
• Species: Human
• Form: Liquid
• Molecular Mass: 118.69 kDa
• Protein Length: 838 amino acids
• AA Sequence: MVCSAAPLLLLATTLPLLGSPVAQA SQPVSETGVRPREGLQRRQWGPLIG RDKAWNERIDRPFPACPIPLSSSFG RWPKGQTMWAQTSTLTLTEEELGQS QAGGESGSGQLLDQENGAGESALVS VYVHLDFPDKTWPPELSRTLTLPAA SASSSPRPLLTGLRLTTECNVNHKG NFYCACLSGYQWNTSICLHYPPCQS LHNHQPCGCLVFSHPEPGYCQLLPP GSPVTCLPAVPGILNLNSQLQMPGD TLSLTLHLSQEATNLSWFLRHPGSP SPILLQPGTQVSVTSSHGQAALSVS NMSHHWAGEYMSCFEAQGFKWNLYE VVRVPLKATDVARLPYQLSISCATS PGFQLSCCIPSTNLAYTAAWSPGEG SKASSFNESGSQCFVLAVQRCPMAD TTYACDLQSLGLAPLRVPISITIIQ DGDITCPEDASVLTWNVTKAGHVAQ APCPESKRGIVRRLCGADGVWGPVH SSCTDARLLALFTRTKLLQAGQGSP AEEVPQILAQLPGQAAEASSPSDLL TLLSTMKYVAKVVAEARIQLDRRAL KNLLIATDKVLDMDTRSLWTLAQAR KPWAGSTLLLAVETLACSLCPQDHP FAFSLPNVLLQSQLFGPTFPADYSI SFPTRPPLQAQIPRHSLAPLVRNGT EISITSLVLRKLDHLLPSNYGQGLG DSLYATPGLVLVISIMAGDRAFSQG EVIMDFGNTDGSPHCVFWDHSLFQG RGGWSKEGCQAQVASASPTAQCLCQ HLTAFSVLMSPHTVPEEPALALLTQ VGLGASILALLVCLGVYWLVWRVVV RNKISYFRHAALLNMVFCLLAADTC FLGAPFLSPGPRSPLCLAAAFLCHF LYLATFFWMLAQALVLAHQLLFVFH QLAKHRVLPLMVLLGYLCPLGLAGV TLGLYLPQGQYLREGECWLDGKGGA LYTFVGPVLAIIGVNGLVLAMAMLK LLRPSLSEGPPAEKRQALLGVIKAL LILTPIFGLTWGLGLATLLEEVSTV PHYIFTILNTLQGVFILLFGCLMDR KIQEALRKRFCRAQAPSSTISLVSC CLQILSCASKSMSEGIPWPSSEDMG TARS
• Applications: Antibody Production
  Functional Study
  Compound Screening
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 25 mM Tris-HCl of pH8.0 containing 2% glycerol.

Gene Information

• Gene Name: ADGRF3 adhesion G protein-coupled receptor F3 [ Homo sapiens (human) ]
• Official Symbol: ADGRF3
• Synonyms: GPR113; G protein-coupled receptor 113; probable G-protein coupled receptor 113; hGPCR37; PGR23; G-protein coupled receptor 113; G protein-coupled receptor PGR23; G-protein coupled receptor PGR23; seven transmembrane helix receptor; FLJ16767
• Gene ID: 165082
• mRNA Refseq: NM_001145168
• Protein Refseq: NP_001138640
• UniProt ID: Q8IZF5

Reviews

04/29/2020

Shows excellent performance in detecting and quantifying the expression levels of recombinant proteins in protein expression analysis.

05/11/2016

Highly specific in detecting and measuring the activity of dehydrogenases in dehydrogenase assays.

Q&As

Does ADGRF3 interact with specific proteins or participate in protein complexes, and if so, what are their functional implications?

ADGRF3 can interact with specific proteins or participate in protein complexes, potentially influencing [specific cellular processes or signaling pathways] and providing functional implications.

Are there any identified genetic variations or mutations in ADGRF3 associated with human diseases or phenotypic traits?

Identified genetic variations or mutations in ADGRF3 have been associated with human diseases or phenotypic traits, such as [specific disease conditions or clinical characteristics], providing insights into its role in [relevant disease mechanisms or phenotypic variations].

What are the downstream signaling pathways activated by ADGRF3 and how do they contribute to cellular functions?

Activation of ADGRF3 triggers downstream signaling pathways, such as [specific signaling cascades], which contribute to cellular functions including [relevant cellular processes or functional outcomes].

What are the physiological and pathological consequences of ADGRF3 knockout or overexpression?

Knockout or overexpression of ADGRF3 results in physiological and pathological consequences, including [specific phenotypic changes or disease manifestations], highlighting its importance in [relevant biological contexts].

What is the expression pattern of ADGRF3 in different tissues and cell types, and how is it regulated under various physiological and pathological conditions?

ADGRF3 exhibits a distinct expression pattern across various tissues and cell types, with regulatory mechanisms that include [specific transcription factors or signaling pathways] under different physiological and pathological conditions.

What is the subcellular localization of ADGRF3 and how does it impact its signaling and functional properties?

ADGRF3 exhibits a specific subcellular localization pattern, primarily localized to [specific cellular compartments, such as plasma membrane or endosomes], which affects its signaling and functional properties.

Does ADGRF3 play a role in specific cellular processes, such as cell proliferation, differentiation, or migration, and if so, what are the underlying mechanisms?

ADGRF3 is implicated in specific cellular processes, such as cell proliferation, differentiation, or migration, involving [specific molecular mechanisms or cellular machinery].

What are the functional differences or similarities between ADGRF3 and other related members of the adhesion G protein-coupled receptor (ADGR) family?

Comparisons between ADGRF3 and other related members of the ADGR family can elucidate functional differences or similarities, providing a broader understanding of the roles of these receptors in [relevant physiological or pathological contexts].

Can the function of ADGRF3 be modulated by pharmacological agents or genetic manipulation?

The function of ADGRF3 can be modulated using pharmacological agents that target [specific receptors or downstream effectors], or through genetic manipulation using [specific genetic tools or techniques].

Are there any known ligands or agonists that specifically bind to ADGRF3 and trigger its activation?

ADGRF3 selectively binds to specific ligands or agonists, such as [specific molecules or peptides], leading to its activation and subsequent signaling events.