Description : |
This gene encodes a basic helix-loop-helix transcription factor belonging to the PAS (PER, ARNT, SIM) superfamily. The PAS proteins play important roles in adaptation to low atmospheric and cellular oxygen levels, exposure to certain environmental pollutants, and diurnal oscillations in light and temperature. This protein forms a transcriptionally active heterodimer with the circadian CLOCK protein, the structurally related MOP4, and hypoxia-inducible factors, such as HIF1alpha. Consistent with its role as a biologically relevant partner of circadian and hypoxia factors, this protein is coexpressed in regions of the brain such as the thalamus, hypothalamus, and amygdala. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011] |
Source : |
In Vitro Cell Free System |
Species : |
Human |
Tag : |
GST |
Molecular Mass : |
90.09 kDa |
Protein Length : |
579 amino acids |
AA Sequence : |
MGKVLREENQ CIAPVVSSRV SPGTRPTAMG SFSSHMTEFP RKRKGSDSDP SQEAHSQTEK RRRDKMNNLI EELSAMIPQC NPMARKLDKL TVLRMAVQHL RSLKGLTNSY VGSNYRPSFL QDNELRHLIL KTAEGFLFVV GCERGKILFV SKSVSKILNY DQASLTGQSL FDFLHPKDVA KVKEQLSSFD ISPREKLIDA KTGLQVHSNL HAGRTRVYSG SRRSFFCRIK SCKISVKEEH GCLPNSKKKE HRKFYTIHCT GYLRSWPPNI VGMEEERNSK KDNSNFTCLV AIGRLQPYIV PQNSGEINVK PTEFITRFAV NGKFVYVDQR ATAILGYLPQ ELLGTSCYEY FHQDDHNNLT DKHKAVLQSK EKILTDSYKF RAKDGSFVTL KSQWFSFTNP WTKELEYIVS VNTLVLGHSE PGEASFLPCS SQSSEESSRQ SCMSVPGMST GTVLGAGSIG TDIANEILDL QRLQSSSYLD DSSPTGLMKD THTVNCRSMS NKELFPPSPS EMGELEATRQ NQSTVAVHSH EPLLSDGAQL DFDALCDNDD TAMAAFMNYL EAEGGLGDPG DFSDIQWTL |
Applications : |
Enzyme-linked Immunoabsorbent Assay; Western Blot (Recombinant protein); Antibody Production; Protein Array |
Storage : |
Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing. |
Storage Buffer : |
50 mM Tris-HCl, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. |