Recombinant Full Length Human CLTCL1 Protein, C-Flag-tagged

• Cat.No.: CLTCL1-1158HFL
• Product Overview: Recombinant Full Length Human CLTCL1 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: This gene is a member of the clathrin heavy chain family and encodes a major protein of the polyhedral coat of coated pits and vesicles. Chromosomal aberrations involving this gene are associated with meningioma, DiGeorge syndrome, and velo-cardio-facial syndrome. Multiple transcript variants encoding different isoforms have been found for this gene.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 186.9 kDa
• AA Sequence: MAQILPVRFQEHFQLQNLGINPANI GFSTLTMESDKFICIREKVGEQAQV TIIDMSDPMAPIRRPISAES AIMNPASKVIALKAGKTLQIFNIEM KSKMKAHTMAEEVIFWKWVSVNTVA LVTETAVYHWSMEGDSQPMK MFDRHTSLVGCQVIHYRTDEYQKWL LLVGISAQQNRVVGAMQLYSVDRKV SQPIEGHAAAFAEFKMEGNA KPATLFCFAVRNPTGGKLHIIEVGQ PAAGNQPFVKKAVDVFFPPEAQNDF PVAMQIGAKHGVIYLITKYG YLHLYDLESGVCICMNRISADTIFV TAPHKPTSGIIGVNKKGQVLSVCVE EDNIVNYATNVLQNPDLGLR LAVRSNLAGAEKLFVRKFNTLFAQG SYAEAAKVAASAPKGILRTRETVQK FQSIPAQSGQASPLLQYFGI LLDQGQLNKLESLELCHLVLQQGRK QLLEKWLKEDKLECSEELGDLVKTT DPMLALSVYLRANVPSKVIQ CFAETGQFQKIVLYAKKVGYTPDWI FLLRGVMKISPEQGLQFSRMLVQDE EPLANISQIVDIFMENSLIQ QCTSFLLDALKNNRPAEGLLQTWLL EMNLVHAPQVADAILGNKMFTHYDR AHIAQLCEKAGLLQQALEHY TDLYDIKRAVVHTHLLNPEWLVNFF GSLSVEDSVECLHAMLSANIRQNLQ LCVQVASKYHEQLGTQALVE LFESFKSYKGLFYFLGSIVNFSQDP DVHLKYIQAACKTGQIKEVERICRE SSCYNPERVKNFLKEAKLTD QLPLIIVCDRFGFVHDLVLYLYRNN LQRYIEIYVQKVNPSRTPAVIGGLL DVDCSEEVIKHLIMAVRGQF STDELVAEVEKRNRLKLLLPWLESQ IQEGCEEPATHNALAKIYIDSNNSP ECFLRENAYYDSSVVGRYCE KRDPHLACVAYERGQCDLELIKVCN ENSLFKSEARYLVCRKDPELWAHVL EETNPSRRQLIDQVVQTALS ETRDPEEISVTVKAFMTADLPNELI ELLEKIVLDNSVFSEHRNLQNLLIL TAIKADRTRVMEYISRLDNY DALDIASIAVSSALYEEAFTVFHKF DMNASAIQVLIEHIGNLDRAYEFAE RCNEPAVWSQLAQAQLQKDL VKEAINSYIRGDDPSSYLEVVQSAS RSNNWEDLVKFLQMARKKGRESYIE TELIFALAKTSRVSELEDFI NGPNNAHIQQVGDRCYEEGMYEAAK LLYSNVSNFARLASTLVHLGEYQAA VDNSRKASSTRTWKEVCFAC MDGQEFRFAQLCGLHIVIHADELEE LMCYYQDRGYFEELILLLEAALGLE RAHMGMFTELAILYSKFKPQ KMLEHLELFWSRVNIPKVLRAAEQA HLWAELVFLYDKYEEYDNAVLTMMS HPTEAWKEGQFKDIITKVAN VELCYRALQFYLDYKPLLINDLLLV LSPRLDHTWTVSFFSKAGQLPLVKP YLRSVQSHNNKSVNEALNHL LTEEEDYQGLRASIDAYDNFDNISL AQQLEKHQLMEFRCIAAYLYKGNNW WAQSVELCKKDHLYKDAMQH AAESRDAELAQKLLQWFLEEGKREC FAACLFTCYDLLRPDMVLELAWRHN LVDLAMPYFIQVMREYLSKV
  DKLDALESLRKQEEHVTEPAPLVFD FDGHETRTRPLEQKLISEEDLAAND ILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome
• Protein Pathways: Endocytosis, Huntington's disease, Lysosome

Gene Information

• Gene Name: CLTCL1 clathrin heavy chain like 1 [ Homo sapiens (human) ]
• Official Symbol: CLTCL1
• Synonyms: CLTD; CHC22; CLH22; CLTCL
• Gene ID: 8218
• mRNA Refseq: NM_007098.4
• Protein Refseq: NP_009029.3
• MIM: 601273
• UniProt ID: P53675