Recombinant Full Length Human CTNNA1 Protein, C-Flag-tagged

• Cat.No.: CTNNA1-623HFL
• Product Overview: Recombinant Full Length Human CTNNA1 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: This gene encodes a member of the catenin family of proteins that play an important role in cell adhesion process by connecting cadherins located on the plasma membrane to the actin filaments inside the cell. The encoded mechanosensing protein contains three vinculin homology domains and undergoes conformational changes in response to cytoskeletal tension, resulting in the reconfiguration of cadherin-actin filament connections. Certain mutations in this gene cause butterfly-shaped pigment dystrophy.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 99.9 kDa
• AA Sequence: MTAVHAGNINFKWDPKSLEIRTLAV ERLLEPLVTQVTTLVNTNSKGPSNK KRGRSKKAHVLAASVEQATE NFLEKGDKIAKESQFLKEELVAAVE DVRKQGDLMKAAAGEFADDPCSSVK RGNMVRAARALLSAVTRLLI LADMADVYKLLVQLKVVEDGILKLR NAGNEQDLGIQYKALKPEVDKLNIM AAKRQQELKDVGHRDQMAAA RGILQKNVPILYTASQACLQHPDVA AYKANRDLIYKQLQQAVTGISNAAQ ATASDDASQHQGGGGGELAY ALNNFDKQIIVDPLSFSEERFRPSL EERLESIISGAALMADSSCTRDDRR ERIVAECNAVRQALQDLLSE YMGNAGRKERSDALNSAIDKMTKKT RDLRRQLRKAVMDHVSDSFLETNVP LLVLIEAAKNGNEKEVKEYA QVFREHANKLIEVANLACSISNNEE GVKLVRMSASQLEALCPQVINAALA LAAKPQSKLAQENMDLFKEQ WEKQVRVLTDAVDDITSIDDFLAVS ENHILEDVNKCVIALQEKDVDGLDR TAGAIRGRAARVIHVVTSEM DNYEPGVYTEKVLEATKLLSNTVMP RFTEQVEAAVEALSSDPAQPMDENE FIDASRLVYDGIRDIRKAVL MIRTPEELDDSDFETEDFDVRSRTS VQTEDDQLIAGQSARAIMAQLPQEQ KAKIAEQVASFQEEKSKLDA EVSKWDDSGNDIIVLAKQMCMIMME MTDFTRGKGPLKNTSDVISAAKKIA EAGSRMDKLGRTIADHCPDS ACKQDLLAYLQRIALYCHQLNICSK VKAEVQNLGGELVVSGVDSAMSLIQ AAKNLMNAVVQTVKASYVAS TKYQKSQGMASLNLPAVSWKMKAPE KKPLVKREKQDETQTKIKRASQKKH VNPVQALSEFKAMDSISGPTRTRPL EQKLISEEDLAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome
• Protein Pathways: Adherens junction, Arrhythmogenic right ventricular cardiomyopathy (ARVC), Endometrial cancer, Leukocyte transendothelial migration, Pathways in cancer, Tight junction

Gene Information

• Gene Name: CTNNA1 catenin alpha 1 [ Homo sapiens (human) ]
• Official Symbol: CTNNA1
• Synonyms: MDPT2; CAP102
• Gene ID: 1495
• mRNA Refseq: NM_001903.5
• Protein Refseq: NP_001894.2
• MIM: 116805
• UniProt ID: P35221