Recombinant Full Length Human DAB2 Protein, C-Flag-tagged

• Cat.No.: DAB2-1985HFL
• Product Overview: Recombinant Full Length Human DAB2 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras), via its C-terminal proline-rich sequences, and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 82.3 kDa
• AA Sequence: MSNEVETSATNGQPDQQAAPKAPSK KEKKKGPEKTDEYLLARFKGDGVKY KAKLIGIDDVPDARGDKMSQ DSMMKLKGMAAAGRSQGQHKQRIWV NISLSGIKIIDEKTGVIEHEHPVNK ISFIARDVTDNRAFGYVCGG EGQHQFFAIKTGQQAEPLVVDLKDL FQVIYNVKKKEEEKKKIEEASKAVE NGSEALMILDDQTNKLKSGV DQMDLFGDMSTPPDLNSPTESKDIL LVDLNSEIDTNQNSLRENPFLTNGI TSCSLPRPTPQASFLPENAF SANLNFFPTPNPDPFRDDPFTQPDQ STPSSFDSLKSPDQKKENSSSSSTP LSNGPLNGDVDYFGQQFDQI SNRTGKQEAQAGPWPFSSSQTQPAV RTQNGVSEREQNGFSVKSSPNPFVG SPPKGLSIQNGVKQDLESSV QSSPHDSIAIIPPPQSTKPGRGRRT AKSSANDLLASDIFAPPVSEPSGQA SPTGQPTALQPNPLDLFKTS APAPVGPLVGLGGVTVTLPQAGPWN TASLVFNQSPSMAPGAMMGGQPSGF SQPVIFGTSPAVSGWNQPSP FAASTPPPVPVVWGPSASVAPNAWS TTSPLGNPFQSNIFPAPAVSTQPPS MHSSLLVTPPQPPPRAGPPK DISSDAFTALDPLGDKEIKDVKEMF KDFQLRQPPVVPARKGEQTSSGTLS AFASYFNSKVGIPQENADHD DFDANQLLNKINEPPKPAPRQVSLP VTKSTDNAFENPFFKDSFGSSQASV ASSQPVSSEMYRDPFGNPFA TRTRPLEQKLISEEDLAANDILDYK DDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome
• Protein Pathways: Endocytosis

Gene Information

• Gene Name: DAB2 DAB adaptor protein 2 [ Homo sapiens (human) ]
• Official Symbol: DAB2
• Synonyms: DOC2; DOC-2
• Gene ID: 1601
• mRNA Refseq: NM_001343.4
• Protein Refseq: NP_001334.2
• MIM: 601236
• UniProt ID: P98082