Recombinant Full Length Human DHX58 Protein, C-Flag-tagged

• Cat.No.: DHX58-2172HFL
• Product Overview: Recombinant Full Length Human DHX58 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: Enables double-stranded RNA binding activity; single-stranded RNA binding activity; and zinc ion binding activity. Involved in negative regulation of defense response and negative regulation of type I interferon production. Predicted to be active in cytoplasm.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 76.4 kDa
• AA Sequence: MELRSYQWEVIMPALEGKNIIIWLP TGAGKTRAAAYVAKRHLETVDGAKV VVLVNRVHLVTQHGEEFRRM LDGRWTVTTLSGDMGPRAGFGHLAR CHDLLICTAELLQMALTSPEEEEHV ELTVFSLIVVDECHHTHKDT VYNVIMSQYLELKLQRAQPLPQVLG LTASPGTGGASKLDGAINHVLQLCA NLDTWCIMSPQNCCPQLQEH SQQPCKQYNLCHRRSQDPFGDLLKK LMDQIHDHLEMPELSRKFGTQMYEQ QVVKLSEAAALAGLQEQRVY ALHLRRYNDALLIHDTVRAVDALAA LQDFYHREHVTKTQILCAERRLLAL FDDRKNELAHLATHGPENPK LEMLEKILQRQFSSSNSPRGIIFTR TRQSAHSLLLWLQQQQGLQTVDIRA QLLIGAGNSSQSTHMTQRDQ QEVIQKFQDGTLNLLVATSVAEEGL DIPHCNVVVRYGLLTNEISMVQARG RARADQSVYAFVATEGSREL KRELINEALETLMEQAVAAVQKMDQ AEYQAKIRDLQQAALTKRAAQAAQR ENQRQQFPVEHVQLLCINCM VAVGHGSDLRKVEGTHHVNVNPNFS NYYNVSRDPVVINKVFKDWKPGGVI SCRNCGEVWGLQMIYKSVKL PVLKVRSMLLETPQGRIQAKKWSRV PFSVPDFDFLQHCAENLSDLSLD SGPTRTRPLEQKLISEEDLAANDIL DYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Pathways: RIG-I-like receptor signaling pathway

Gene Information

• Gene Name: DHX58 DExH-box helicase 58 [ Homo sapiens (human) ]
• Official Symbol: DHX58
• Synonyms: LGP2; RLR-3; D11LGP2; D11lgp2e
• Gene ID: 79132
• mRNA Refseq: NM_024119.3
• Protein Refseq: NP_077024.2
• MIM: 608588
• UniProt ID: Q96C10