Recombinant Full Length Human EXO5 Protein, GST-tagged

• Cat.No.: EXO5-2458HF
• Product Overview: Human DEM1 full-length ORF ( NP_073611.1, 1 a.a. - 373 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: The protein encoded by this gene is a single-stranded DNA (ssDNA)-specific exonuclease that can slide along the DNA before cutting it. However, human replication protein A binds ssDNA and restricts sliding of the encoded protein, providing a 5'-directionality to the enzyme. This protein localizes to nuclear repair loci after DNA damage. [provided by RefSeq, Nov 2016]
• Source: In Vitro Cell Free System
• Species: Human
• Tag: GST
• Molecular Mass: 68.2 kDa
• Protein Length: 373 amino acids
• AA Sequence: MAETREEETVSAEASGFSDLSDSEF LEFLDLEDAQESKALVNMPGPSSES LGKDDKPISLQNWKRGLDILSPMER FHLKYLYVTDLATQNWCELQTAYGK ELPGFLAPEKAAVLDTGASIHLARE LELHDLVTVPVTTKEDAWAIKFLNI LLLIPTLQSEGHIREFPVFGEGEGV LLVGVIDELHYTAKGELELAELKTR RRPMLPLEAQKKKDCFQVSLYKYIF DAMVQGKVTPASLIHHTKLCLEKPL GPSVLRHAQQGGFSVKSLGDLMELV FLSLTLSDLPVIDILKIEYIHQETA TVLGTEIVAFKEKEVRAKVQHYMAY WMGHREPQGVDVEEAWKCRTCTYAD ICEWRKGSGVLSSTLAPQVKKAK
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCl, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: EXO5 exonuclease 5 [ Homo sapiens (human) ]
• Official Symbol: EXO5
• Synonyms: DEM1; defects in morphology 1 homolog (S. cerevisiae); C1orf176, chromosome 1 open reading frame 176; probable exonuclease V; FLJ21144; defects in morphology protein 1 homolog; Exo V; C1orf176; FLJ11445; FLJ13183; EXO5; exonuclease 5
• Gene ID: 64789
• mRNA Refseq: NM_022774
• Protein Refseq: NP_073611
• MIM: 618601
• UniProt ID: Q9H790