Recombinant Full Length Human GALE Protein, GST-tagged
Cat.No. : | GALE-5226HF |
Product Overview : | Human GALE full-length ORF ( AAH01273, 1 a.a. - 348 a.a.) recombinant protein with GST-tag at N-terminal. |
- Specification
- Gene Information
- Related Products
Description : | This gene encodes UDP-galactose-4-epimerase which catalyzes two distinct but analogous reactions: the epimerization of UDP-glucose to UDP-galactose, and the epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. The bifunctional nature of the enzyme has the important metabolic consequence that mutant cells (or individuals) are dependent not only on exogenous galactose, but also on exogenous N-acetylgalactosamine as a necessary precursor for the synthesis of glycoproteins and glycolipids. Mutations in this gene result in epimerase-deficiency galactosemia, also referred to as galactosemia type 3, a disease characterized by liver damage, early-onset cataracts, deafness and mental retardation, with symptoms ranging from mild (peripheral form) to severe (generalized form). Multiple alternatively spliced transcripts encoding the same protein have been identified. [provided by RefSeq |
Source : | In Vitro Cell Free System |
Species : | Human |
Tag : | GST |
Molecular Mass : | 64.02 kDa |
Protein Length : | 348 amino acids |
AA Sequence : | MAEKVLVTGGAGYIGSHTVLELLEA GYLPVVIDNFHNAFRGGGSLPESLR RVQELTGRSVEFEEMDILDQGALQR LFKKYSFMAVIHFAGLKAVGESVQK PLDYYRVNLTGTIQLLEIMKAHGVK NLVFSSSATVYGNPQYLPLDEAHPT GGCTNPYGKSKFFIEEMIRDLCQAD KTWNAVLLRYFNPTGAHASGCIGED PQGIPNNLMPYVSQVAIGRREALNV FGNDYDTEDGTGVRDYIHVVDLAKG HIAALRKLKEQCGCRIYNLGTGTGY SVLQMVQAMEKASGKKIPYKVVARR EGDVAACYANPSLAQEELGWTAALG LDRMCEDLWRWQKQNPSGFGTQA |
Applications : | Enzyme-linked Immunoabsorbent Assay Western Blot (Recombinant protein) Antibody Production Protein Array |
Notes : | Best use within three months from the date of receipt of this protein. |
Storage : | Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing. |
Storage Buffer : | 50 mM Tris-HCl, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. |
Gene Name : | GALE UDP-galactose-4-epimerase [ Homo sapiens ] |
Official Symbol : | GALE |
Synonyms : | GALE; UDP-galactose-4-epimerase; galactose 4 epimerase, UDP; UDP-glucose 4-epimerase; SDR1E1; short chain dehydrogenase/reductase family 1E; member 1; UDP glucose 4 epimerase; galactowaldenase; UDP-galactose 4-epimerase; UDP galactose-4-epimerase; galactose-4-epimerase, UDP-; short chain dehydrogenase/reductase family 1E, member 1; FLJ95174; FLJ97302; |
Gene ID : | 2582 |
mRNA Refseq : | NM_000403 |
Protein Refseq : | NP_000394 |
MIM : | 606953 |
UniProt ID : | Q14376 |
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◆ Lysates | ||
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Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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