Recombinant Full Length Human GCLC Protein, C-Flag-tagged
Cat.No. : | GCLC-881HFL |
Product Overview : | Recombinant Full Length Human GCLC Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells. |
- Specification
- Gene Information
- Related Products
Description : | Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase is the first rate-limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. This locus encodes the catalytic subunit, while the regulatory subunit is derived from a different gene located on chromosome 1p22-p21. Mutations at this locus have been associated with hemolytic anemia due to deficiency of gamma-glutamylcysteine synthetase and susceptibility to myocardial infarction. |
Source : | Mammalian cells |
Species : | Human |
Tag : | Flag |
Form : | 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Molecular Mass : | 72.6 kDa |
AA Sequence : | MGLLSQGSPLSWEETKRHADHVRRH GILQFLHIYHAVKDRHKDVLKWGDE VEYMLVSFDHENKKVRLVLS GEKVLETLQEKGERTNPNHPTLWRP EYGSYMIEGTPGQPYGGTMSEFNTV EANMRKRRKEATSILEENQA LCTITSFPRLGCPGFTLPEVKPNPV EGGASKSLFFPDEAINKHPRFSTLT RNIRHRRGEKVVINVPIFKD KNTPSPFIETFTEDDEASRASKPDH IYMDAMGFGMGNCCLQVTFQACSIS EARYLYDQLATICPIVMALS AASPFYRGYVSDIDCRWGVISASVD DRTREERGLEPLKNNNYRISKSRYD SIDSYLSKCGEKYNDIDLTI DKEIYEQLLQEGIDHLLAQHVAHLF IRDPLTLFEEKIHLDDANESDHFEN IQSTNWQTMRFKPPPPNSDI GWRVEFRPMEVQLTDFENSAYVVFV VLLTRVILSYKLDFLIPLSKVDENM KVAQKRDAVLQGMFYFRKDI CKGGNAVVDGCGKAQNSTELAAEEY TLMSIDTIINGKEGVFPGLIPILNS YLENMEVDVDTRCSILNYLK LIKKRASGELMTVARWMREFIANHP DYKQDSVITDEMNYSLILKCNQIAN ELCECPELLGSAFRKVKYSG SKTDSSNTRTRPLEQKLISEEDLAA NDILDYKDDDDKV |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining. |
Stability : | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Storage : | Store at -80 centigrade. |
Concentration : | >50 ug/mL as determined by microplate BCA method. |
Preparation : | Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
Protein Families : | Druggable Genome |
Protein Pathways : | Glutathione metabolism, Metabolic pathways |
Gene Name : | GCLC glutamate-cysteine ligase catalytic subunit [ Homo sapiens (human) ] |
Official Symbol : | GCLC |
Synonyms : | GCL; GCS; GLCL; GLCLC |
Gene ID : | 2729 |
mRNA Refseq : | NM_001498.4 |
Protein Refseq : | NP_001489.1 |
MIM : | 606857 |
UniProt ID : | P48506 |
Products Types
◆ Recombinant Protein | ||
GCLC-2148R | Recombinant Rat GCLC Protein, His (Fc)-Avi-tagged | +Inquiry |
GCLC-4800H | Recombinant Human GCLC Protein, GST-tagged | +Inquiry |
GCLC-668H | Recombinant Human GCLC Protein, MYC/DDK-tagged | +Inquiry |
GCLC-3507M | Recombinant Mouse GCLC Protein, His (Fc)-Avi-tagged | +Inquiry |
GCLC-973H | Recombinant Human GCLC Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
GCLC-5983HCL | Recombinant Human GCLC 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
0
Inquiry Basket