Recombinant Full Length Human GCLM Protein

• Cat.No.: GCLM-193HF
• Product Overview: Recombinant full length Human GCLM with N terminal proprietary tag; Predicted MWt 56.25 kDa including the tag.

Specification

• Description: Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase, is the first rate limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. Gamma glutamylcysteine synthetase deficiency has been implicated in some forms of hemolytic anemia.
• Source: In Vitro Cell Free System
• Species: Human
• Form: Liquid
• Molecular Mass: 56.250kDa inclusive of tags
• Protein Length: 274 amino acids
• AA Sequence: MGTDSRAAKALLARARTLHLQTGNLLNWGRLRKKCPSTHS EELHDCIQKTLNEWSSQINPDLVREFPDVLECTVSHAVEK INPDEREEMKVSAKLFIVESNSSSSTRSAVDMACSVLGVA QLDSVIIASPPIEDGVNLSLEHLQPYWEELENLVQSKKIV AIGTSDLDKTQLEQLYQWAQVKPNSNQVNLASCCVMPPDL TAFAKQFDIQLLTHNDPKELLSGASFQEALQESIPDIQAH EWVPLWLLRYSVIVKSRGIIKSKGYILQAKRRGS
• Purity: Proprietary Purification
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80 centigrade. Avoid freeze / thaw cycles.
• Storage Buffer: pH: 8.00. Constituents:0.79% Tris HCl, 0.31% Glutathione.

Gene Information

• Gene Name: GCLM glutamate-cysteine ligase, modifier subunit [ Homo sapiens ]
• Official Symbol: GCLM
• Synonyms: GCLM; glutamate-cysteine ligase, modifier subunit; GLCLR; glutamate--cysteine ligase regulatory subunit; gamma glutamylcysteine synthetase
• Gene ID: 2730
• mRNA Refseq: NM_002061
• Protein Refseq: NP_002052
• MIM: 601176
• UniProt ID: P48507