Recombinant Full Length Human ITPKC Protein, C-Flag-tagged

• Cat.No.: ITPKC-1791HFL
• Product Overview: Recombinant Full Length Human ITPKC Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: This gene encodes a member of the inositol 1,4,5-trisphosphate [Ins(1,4,5)P(3)] 3-kinase family of enzymes that catalyze the phosphorylation of inositol 1,4,5-trisphosphate to 1,3,4,5-tetrakisphosphate. The encoded protein is localized to the nucleus and cytoplasm and has both nuclear import and nuclear export activity. Single nucleotide polymorphisms in this gene are associated with Kawasaki disease.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 75 kDa
• AA Sequence: MRRCPCRGSLNEAEAGALPAAARMG LEAPRGGRRRQPGQQRPGPGAGAPA GRPEGGGPWARTEGSSLHSE PERAGLGPAPGTESPQAEFWTDGQT EPAAAGLGVETERPKQKTEPDRSSL RTHLEWSWSELETTCLWTET GTDGLWTDPHRSDLQFQPEEASPWT QPGVHGPWTELETHGSQTQPERVKS WADNLWTHQNSSSLQTHPEG ACPSKEPSADGSWKELYTDGSRTQQ DIEGPWTEPYTDGSQKKQDTEAARK QPGTGGFQIQQDTDGSWTQP STDGSQTAPGTDCLLGEPEDGPLEE PEPGELLTHLYSHLKCSPLCPVPRL IITPETPEPEAQPVGPPSRV EGGSGGFSSASSFDESEDDVVAGGG GASDPEDRSGSKPWKKLKTVLKYSP FVVSFRKHYPWVQLSGHAGN FQAGEDGRILKRFCQCEQRSLEQLM KDPLRPFVPAYYGMVLQDGQTFNQM EDLLADFEGPSIMDCKMGSR TYLEEELVKARERPRPRKDMYEKMV AVDPGAPTPEEHAQGAVTKPRYMQW RETMSSTSTLGFRIEGIKKA DGTCNTNFKKTQALEQVTKVLEDFV DGDHVILQKYVACLEELREALEISP FFKTHEVVGSSLLFVHDHTG LAKVWMIDFGKTVALPDHQTLSHRL PWAEGNREDGYLWGLDNMICLLQGL AQS TRTRPLEQKLISEEDLAANDILDYK DDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome

Gene Information

• Gene Name: ITPKC inositol-trisphosphate 3-kinase C [ Homo sapiens (human) ]
• Official Symbol: ITPKC
• Synonyms: IP3KC; IP3-3KC
• Gene ID: 80271
• mRNA Refseq: NM_025194.3
• Protein Refseq: NP_079470.1
• MIM: 606476
• UniProt ID: Q96DU7