Recombinant Full Length Human KCTD13 Protein, His tagged

• Cat.No.: KCTD13-21HFL
• Product Overview: Purified recombinant protein of Homo sapiens potassium channel tetramerisation domain containing 13 (KCTD13), full length, with N-terminal His tag, expressed in E.coli.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: 1-329 aa
• Description: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for synaptic transmission. The BCR (KCTD13) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome. Degradation of RHOA regulates the actin cytoskeleton and promotes synaptic transmission.
• Form: 25 mM Tris-HCl, pH 8.0, 150 mM NaCl, 1% sarkosyl, 10% glycerol
• Molecular Mass: 36.2 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Notes: For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process.
• Storage: Store at -80 centigrade. Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Concentration: >0.05 μg/μL as determined by microplate BCA method
• Shipping: Dry Ice

Gene Information

• Gene Name: KCTD13 potassium channel tetramerisation domain containing 13 [ Homo sapiens (human) ]
• Official Symbol: KCTD13
• Synonyms: KCTD13; potassium channel tetramerisation domain containing 13; BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1; FKSG86; PDIP1; POLDIP1; polymerase delta interacting protein 1; TNFAIP1 like; TNFAIP1-like protein; polymerase delta-interacting protein 1; BTB/POZ domain-containing protein KCTD13; hBACURD1
• Gene ID: 253980
• mRNA Refseq: NM_178863
• Protein Refseq: NP_849194
• MIM: 608947
• UniProt ID: Q8WZ19