Recombinant Full Length Human KDM4A Protein, C-Flag-tagged

• Cat.No.: KDM4A-1991HFL
• Product Overview: Recombinant Full Length Human KDM4A Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: This gene is a member of the Jumonji domain 2 (JMJD2) family and encodes a protein containing a JmjN domain, a JmjC domain, a JD2H domain, two TUDOR domains, and two PHD-type zinc fingers. This nuclear protein functions as a trimethylation-specific demethylase, converting specific trimethylated histone residues to the dimethylated form, and as a transcriptional repressor.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 120.5 kDa
• AA Sequence: MASESETLNPSARIMTFYPTMEEFR NFSRYIAYIESQGAHRAGLAKVVPP KEWKPRASYDDIDDLVIPAP IQQLVTGQSGLFTQYNIQKKAMTVR EFRKIANSDKYCTPRYSEFEELERK YWKNLTFNPPIYGADVNGTL YEKHVDEWNIGRLRTILDLVEKESG ITIEGVNTPYLYFGMWKTSFAWHTE DMDLYSINYLHFGEPKSWYS VPPEHGKRLERLAKGFFPGSAQSCE AFLRHKMTLISPLMLKKYGIPFDKV TQEAGEFMITFPYGYHAGFN HGFNCAESTNFATRRWIEYGKQAVL CSCRKDMVKISMDVFVRKFQPERYK LWKAGKDNTVIDHTLPTPEA AEFLKESELPPRAGNEEECPEEDME GVEDGEEGDLKTSLAKHRIGTKRHR VCLEIPQEVSQSELFPKEDL SSEQYEMTECPAALAPVRPTHSSVR QVEDGLTFPDYSDSTEVKFEELKNV KLEEEDEEEEQEAAALDLSV NPASVGGRLVFSGSKKKSSSSLGSG SSRDSISSDSETSEPLSCRAQGQTG VLTVHSYAKGDGRVTVGEPC TRKKGSAARSFSERELAEVADEYMF SLEENKKSKGRRQPLSKLPRHHPLV LQECVSDDETSEQLTPEEEA EETEAWAKPLSQLWQNRPPNFEAEK EFNETMAQQAPHCAVCMIFQTYHQV EFGGFNQNCGNASDLAPQKQ RTKPLIPEMCFTSTGCSTDINLSTP YLEEDGTSILVSCKKCSVRVHASCY GVPPAKASEDWMCSRCSANA LEEDCCLCSLRGGALQRANDDRWVH VSCAVAILEARFVNIAERSPVDVSK IPLPRFKLKCIFCKKRRKRT AGCCVQCSHGRCPTAFHVSCAQAAG VMMQPDDWPFVVFITCFRHKIPNLE RAKGALQSITAGQKVISKHK NGRFYQCEVVRLTTETFYEVNFDDG SFSDNLYPEDIVSQDCLQFGPPAEG EVVQVRWTDGQVYGAKFVAS HPIQMYQVEFEDGSQLVVKRDDVYT LDEELPKRVKSRLSVASDMRFNEIF TEKEVKQEKKRQRVINSRYR EDYIEPALYRAIME TRTRPLEQKLISEEDLAANDILDYK DDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome, Transcription Factors

Gene Information

• Gene Name: KDM4A lysine demethylase 4A [ Homo sapiens (human) ]
• Official Symbol: KDM4A
• Synonyms: JMJD2; JHDM3A; JMJD2A; TDRD14A
• Gene ID: 9682
• mRNA Refseq: NM_014663.3
• Protein Refseq: NP_055478.2
• MIM: 609764
• UniProt ID: O75164