Recombinant Full Length Human KRIT1 Protein, GST-tagged

• Cat.No.: KRIT1-5917HF
• Product Overview: Human KRIT1 full-length ORF ( NP_004903.2, 1 a.a. - 736 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: This gene encodes a protein containing four ankyrin repeats, a band 4.1/ezrin/radixin/moesin (FERM) domain, and multiple NPXY sequences. The encoded protein is localized in the nucleus and cytoplasm. It binds to integrin cytoplasmic domain-associated protein-1 alpha (ICAP1alpha), and plays a critical role in beta1-integrin-mediated cell proliferation. It associates with junction proteins and RAS-related protein 1A (Rap1A), which requires the encoded protein for maintaining the integrity of endothelial junctions. It is also a microtubule-associated protein and may play a role in microtubule targeting. Mutations in this gene result in cerebral cavernous malformations. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq
• Source: In Vitro Cell Free System
• Species: Human
• Tag: GST
• Molecular Mass: 110.7 kDa
• Protein Length: 736 amino acids
• AA Sequence: MGNPENIEDAYVAVIRPKNTASLNS REYRAKSYEILLHEVPIEGQKKKRK KVLLETKLQGNSEITQGILDYVVET TKPISPANQGIRGKRVVLMKKFPLD GEKMGREASLFIVPSVVKDNTKYTY TPGCPIFYCLQDIMRVCSESSTHFA TLTARMLIALDKWLDERHAQSHFIP ALFRPSPLERIKTNVINPAYATESG QTENSLHMGYSALEIKSKMLALEKA DTCIYNPLFGSDLQYTNRVDKVVIN PYFGLGAPDYSKIQIPKQEKWQRSM SSVTEDKERQWVDDFPLHRSACEGD SELLSRLLSERFSVNQLDSDHWAPI HYACWYGKVEATRILLEKGKCNPNL LNGQLSSPLHFAAGGGHAEIVQILL NHPETDRHITDQQGRSPLNICEENK QNNWEEAAKLLKEAINKPYEKVRIY RMDGSYRSVELKHGNNTTVQQIMEG MRLSQETQQYFTIWICSENLSLQLK PYHKPLQHVRDWPEILAELTNLDPQ RETPQLFLRRDVRLPLEVEKQIEDP LAILILFDEARYNLLKGFYTAPDAK LITLASLLLQIVYGNYESKKHKQGF LNEENLKSIVPVTKLKSKAPHWTNR ILHEYKNLSTSEGVSKEMHHLQRMF LQNCWEIPTYGAAFFTGQIFTKASP SNHKVIPVYVGVNIKGLHLLNMETK ALLISLKYGCFMWQLGDTDTCFQIH SMENKMSFIVHTKQAGLVVKLLMKL NGQLMPTERNS
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCl, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: KRIT1 KRIT1, ankyrin repeat containing [ Homo sapiens ]
• Official Symbol: KRIT1
• Synonyms: KRIT1; KRIT1, ankyrin repeat containing; CCM1, cerebral cavernous malformations 1; krev interaction trapped protein 1; CAM; krev interaction trapped 1; ankyrin repeat-containing protein Krit1; cerebral cavernous malformations 1 protein; CCM1
• Gene ID: 889
• mRNA Refseq: NM_001013406
• Protein Refseq: NP_001013424
• MIM: 604214
• UniProt ID: O00522