Recombinant Full Length Human LSS Protein, C-Flag-tagged

• Cat.No.: LSS-1516HFL
• Product Overview: Recombinant Full Length Human LSS Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: The protein encoded by this gene catalyzes the conversion of (S)-2,3 oxidosqualene to lanosterol. The encoded protein is a member of the terpene cyclase/mutase family and catalyzes the first step in the biosynthesis of cholesterol, steroid hormones, and vitamin D. Alternative splicing results in multiple transcript variants encoding different isoforms.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 83.1 kDa
• AA Sequence: MTEGTCLRRRGGPYKTEPATDLGRW RLNCERGRQTWTYLQDERAGREQTG LEAYALGLDTKNYFKDLPKA HTAFEGALNGMTFYVGLQAEDGHWT GDYGGPLFLLPGLLITCHVARIPLP AGYREEIVRYLRSVQLPDGG WGLHIEDKSTVFGTALNYVSLRILG VGPDDPDLVRARNILHKKGGAVAIP SWGKFWLAVLNVYSWEGLNT LFPEMWLFPDWAPAHPSTLWCHCRQ VYLPMSYCYAVRLSAAEDPLVQSLR QELYVEDFASIDWLAQRNNV APDELYTPHSWLLRVVYALLNLYEH HHSAHLRQRAVQKLYEHIVADDRFT KSISIGPISKTINMLVRWYV DGPASTAFQEHVSRIPDYLWMGLDG MKMQGTNGSQIWDTAFAIQALLEAG GHHRPEFSSCLQKAHEFLRL SQVPDNPPDYQKYYRQMRKGGFSFS TLDCGWIVSDCTAEALKAVLLLQEK CPHVTEHIPRERLCDAVAVL LNMRNPDGGFATYETKRGGHLLELL NPSEVFGDIMIDYTYVECTSAVMQA LKYFHKRFPEHRAAEIRETL TQGLEFCRRQQRADGSWEGSWGVCF TYGTWFGLEAFACMGQTYRDGTACA EVSRACDFLLSRQMADGGWG EDFESCEERRYLQSAQSQIHNTCWA MMGLMAVRHPDIEAQERGVRCLLEK QLPNGDWPQENIAGVFNKSC
  AISYTSYRNIFPIWALGRFSQLYPE RALAGHPTRTRPLEQKLISEEDLAA NDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome
• Protein Pathways: Metabolic pathways, Steroid biosynthesis

Gene Information

• Gene Name: LSS lanosterol synthase [ Homo sapiens (human) ]
• Official Symbol: LSS
• Synonyms: OSC; APMR4; HYPT14; CTRCT44
• Gene ID: 4047
• mRNA Refseq: NM_001001438.3
• Protein Refseq: NP_001001438.1
• MIM: 600909
• UniProt ID: P48449