Recombinant Full Length Human MCM6 Protein
| Cat.No. : | MCM6-299HF |
| Product Overview : | Recombinant full length Human MCM6 (aa 1-821) with N-terminal proprietary tag, 116.38 kDa. |
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| Species : | Human |
| Source : | In Vitro Cell Free System |
| Protein Length : | 821 amino acids |
| Description : | The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of the complex by CDC2 kinase reduces the helicase activity, suggesting a role in the regulation of DNA replication. |
| Form : | Liquid |
| Molecular Mass : | 116.380kDa inclusive of tags |
| AA Sequence : | MDLAAAAEPGAGSQHLEVRDEVAEKCQKLFLDFLEEFQSS DGEIKYLQLAEELIRPERNTLVVSFVDLEQFNQQLSTTIQ EEFYRVYPYLCRALKTFVKDRKEIPLAKDFYVAFQDLPTR HKIRELTSSRIGLLTRISGQVVRTHPVHPELVSGTFLCLD CQTVIRDVEQQFKYTQPNICRNPVCANRRRFLLDTNKSRF VDFQKVRIQETQAELPRGSIPRSLEVILRAEAVESAQAGD KCDFTGTLIVVPDVSKLSTPGARAETNSRVSGVDGYETEG IRGLRALGVRDLSYRLVFLACCVAPTNPRFGGKELRDEEQ TAESIKNQMTVKEWEKVFEMSQDKNLYHNLCTSLFPTIHG NDEVKRGVLLMLFGGVPKTTGEGTSLRGDINVCIVGDPST AKSQFLKHVEEFSPRAVYTSGKASSAAGLTAAVVRDEESH EFVIEAGALMLADNGVCCIDEFDKMDVRDQVAIHEAMEQQ TISITKAGVKATLNARTSILAAANPISGHYDRSKSLKQNI NLSAPIMSRFDLFFILVDECNEVTDYAIARRIVDLHSRIE ESIDRVYSLDDIRRYLLFARQFKPKISKESEDFIVEQYKH LRQRDGSGVTKSSWRITVRQLESMIRLSEAMARMHCCDEV QPKHVKEAFRLLNKSIIRVETPDVNLDQEEEIQMEVDEGA GGINGHADSPAPVNGINGYNEDINQESAPKASLRLGFSEY CRISNLIVLHLRKVEEEEDESALKRSELVNWYLKEIESEI DSEEELINKKRIIEKVIHRLTHYDHVLIELTQAGLKGSTE GSESYEEDPYLVVNPNYLLED |
| Purity : | Proprietary Purification |
| Storage : | Shipped on dry ice. Upon delivery aliquot and store at -80 centigrade. Avoid freeze / thaw cycles. |
| Storage Buffer : | pH: 8.00. Constituents:0.79% Tris HCl, 0.31% Glutathione. |
| Gene Name | MCM6 minichromosome maintenance complex component 6 [ Homo sapiens ] |
| Official Symbol | MCM6 |
| Synonyms | MCM6; minichromosome maintenance complex component 6; MCM6 minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe) (S. cerevisiae) , minichromosome maintenance deficient (mis5, S. pombe) 6 , minichromosome maintenance deficient 6 homolog (S. cer |
| Gene ID | 4175 |
| mRNA Refseq | NM_005915 |
| Protein Refseq | NP_005906 |
| MIM | 601806 |
| UniProt ID | Q14566 |
Not For Human Consumption!
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