| Description : |
The product of this gene is a component of the nuclear cap-binding protein complex (CBC), which binds to the monomethylated 5 cap of nascent pre-mRNA in the nucleoplasm. The encoded protein promotes high-affinity mRNA-cap binding and associates with the CTD of RNA polymerase II. The CBC promotes pre-mRNA splicing, 3-end processing, RNA nuclear export, and nonsense-mediated mRNA decay. |
| Source : |
In Vitro Cell Free System |
| Species : |
Human |
| Form : |
Liquid |
| Molecular Mass : |
112.640kDa inclusive of tags |
| Protein Length : |
790 amino acids |
| AA Sequence : |
MSRRRHSDENDGGQPHKRRKTSDANETEDHLESLICKVGE KSACSLESNLEGLAGVLEADLPNYKSKILRLLCTVARLLP EKLTIYTTLVGLLNARNYNFGGEFVEAMIRQLKESLKANN YNEAVYLVRFLSDLVNCHVIAAPSMVAMFENFVSVTQEED VPQVRRDWYVYAFLSSLPWVGKELYEKKDAEMDRIFANTE SYLKRRQKTHVPMLQVWTADKPHPQEEYLDCLWAQIQKLK KDRWQERHILRPYLAFDSILCEALQHNLPPFTPPPHTEDS VYPMPRVIFRMFDYTDDPEGPVMPGSHSVERFVIEENLHC IIKSHWKERKTCAAQLVSYPGKNKIPLNYHIVEVIFAELF QLPAPPHIDVMYTTLLIELCKLQPGSLPQVLAQATEMLYM RLDTMNTTCVDRFINWFSHHLSNFQFRWSWEDWSDCLSQD PESPKPKFVREVLEKCMRLSYHQRILDIVPPTFSALCPAN PTCIYKYGDESSNSLPGHSVALCLAVAFKSKATNDEIFSI LKDVPNPNQDDDDDEGFSFNPLKIEVFVQTLLHLAAKSFS HSFSALAKFHEVFKTLAESDEGKLHVLRVMFEVWRNHPQM IAVLVDKMIRTQIVDCAAVANWIFSSELSRDFTRLFVWEI LHSTIRKMNKHVLKIQKELEEAKEKLARQHKRRSDDDDRS SDRKDGVLEEQIERLQEKVESAQSEQKNLFLVIFQRFIMI LTEHLVRCETDGTSVLTPWYKNCIERLQQIFLQHHQIIQQ YMVTLENLLFTAELDPHILAVFQQFCALQA |
| Purity : |
Proprietary Purification |
| Storage : |
Shipped on dry ice. Upon delivery aliquot and store at -80 centigrade. Avoid freeze / thaw cycles. |
| Storage Buffer : |
pH: 8.00. Constituents:0.79% Tris HCl, 0.31% Glutathione. |
