Recombinant Full Length Human NEO1 Protein, C-Flag-tagged

• Cat.No.: NEO1-507HFL
• Product Overview: Recombinant Full Length Human NEO1 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: This gene encodes a cell surface protein that is a member of the immunoglobulin superfamily. The encoded protein consists of four N-terminal immunoglobulin-like domains, six fibronectin type III domains, a transmembrane domain and a C-terminal internal domain that shares homology with the tumor suppressor candidate gene DCC. This protein may be involved in cell growth and differentiation and in cell-cell adhesion. Defects in this gene are associated with cell proliferation in certain cancers. Alternate splicing results in multiple transcript variants.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 156.4 kDa
• AA Sequence: MAAERGARRLLSTPSFWLYCLLLLG RRAPGAAAARSGSAPQSPGASIRTF TPFYFLVEPVDTLSVRGSSV ILNCSAYSEPSPKIEWKKDGTFLNL VSDDRRQLLPDGSLFISNVVHSKHN KPDEGYYQCVATVESLGTII SRTAKLIVAGLPRFTSQPEPSSVYA GNNAILNCEVNADLVPFVRWEQNRQ PLLLDDRVIKLPSGMLVISN ATEGDGGLYRCVVESGGPPKYSDEV ELKVLPDPEVISDLVFLKQPSPLVR VIGQDVVLPCVASGLPTPTI KWMKNEEALDTESSERLVLLAGGSL EISDVTEDDAGTYFCIADNGNETIE AQAELTVQAQPEFLKQPTNI YAHESMDIVFECEVTGKPTPTVKWV KNGDMVIPSDYFKIVKEHNLQVLGL VKSDEGFYQCIAENDVGNAQ AGAQLIILEHAPATTGPLPSAPRDV VASLVSTRFIKLTWRTPASDPHGDN LTYSVFYTKEGIARERVENT SHPGEMQVTIQNLMPATVYIFRVMA QNKHGSGESSAPLRVETQPEVQLPG PAPNLRAYAASPTSITVTWE TPVSGNGEIQNYKLYYMEKGTDKEQ DVDVSSHSYTINGLKKYTEYSFRVV AYNKHGPGVSTPDVAVRTLS DVPSAAPQNLSLEVRNSKSIMIHWQ PPAPATQNGQITGYKIRYRKASRKS DVTETLVSGTQLSQLIEGLD RGTEYNFRVAALTINGTGPATDWLS AETFESDLDETRVPEVPSSLHVRPL VTSIVVSWTPPENQNIVVRG YAIGYGIGSPHAQTIKVDYKQRYYT IENLDPSSHYVITLKAFNNVGEGIP LYESAVTRPHTDTSEVDLFV INAPYTPVPDPTPMMPPVGVQASIL SHDTIRITWADNSLPKHQKITDSRY YTVRWKTNIPANTKYKNANA TTLSYLVTGLKPNTLYEFSVMVTKG RRSSTWSMTAHGTTFELVPTSPPKD VTVVSKEGKPKTIIVNWQPP SEANGKITGYIIYYSTDVNAEIHDW VIEPVVGNRLTHQIQELTLDTPYYF KIQARNSKGMGPMSEAVQFR TPKADSSDKMPNDQASGSGGKGSRL PDLGSDYKPPMSGSNSPHGSPTSPL DSNMLLVIIVSVGVITIVVV VIIAVFCTRRTTSHQKKKRAACKSV NGSHKYKGNSKDVKPPDLWIHHERL ELKPIDKSPDPNPIMTDTPI PRNSQDITPVDNSMDSNIHQRRNSY RGHESEDSMSTLAGRRGMRPKMMMP FDSQPPQPVISAHPIHSLDN PHHHFHSSSLASPARSHLYHPGSPW PIGTSMSLSDRANSTESVRNTPSTD TMPASSSQTCCTDHQDPEGA TSSSYLASSQEEDSGQSLPTAHVRP SHPLKSFAVPAIPPPGPPTYDPALP STPLLSQQALNHHIHSVKTA
  SIGTLGRSRPPMPVVVPSAPEVQET TRMLEDSESSYEPDELTKEMAHLEG LMKDLNAITTATRTRPLEQKLISEE DLAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Cell adhesion molecules (CAMs)

Gene Information

• Gene Name: NEO1 neogenin 1 [ Homo sapiens (human) ]
• Official Symbol: NEO1
• Synonyms: NGN; IGDCC2; NTN1R2
• Gene ID: 4756
• mRNA Refseq: NM_002499.4
• Protein Refseq: NP_002490.2
• MIM: 601907
• UniProt ID: Q92859