Recombinant Full Length Human PRKG2 Protein, C-Flag-tagged

• Cat.No.: PRKG2-1299HFL
• Product Overview: Recombinant Full Length Human PRKG2 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: This gene encodes a protein that belongs to the serine/threonine protein kinase family of proteins. The encoded protein binds to and inhibits the activation of several receptor tyrosine kinases. The membrane-bound protein is a regulator of intestinal secretion, bone growth and renin secretion. Alternate splicing results in multiple transcript variants encoding distinct isoforms whose regulatory N-termini differ in length but whose C-terminal catalytic domains are identical.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 87.3 kDa
• AA Sequence: MGNGSVKPKHSKHPDGHSGNLTTDA LRNKVTELERELRRKDAEIQEREYH LKELREQLSKQTVAIAELTE ELQNKCIQLNKLQDVVHMQGGSPLQ ASPDKVPLEVHRKTSGLVSLHSRRG AKAGVSAEPTTRTYDLNKPP EFSFEKARVRKDSSEKKLITDALNK NQFLKRLDPQQIKDMVECMYGRNYQ QGSYIIKQGEPGNHIFVLAE GRLEVFQGEKLLSSIPMWTTFGELA ILYNCTRTASVKAITNVKTWALDRE VFQNIMRRTAQARDEQYRNF LRSVSLLKNLPEDKLTKIIDCLEVE YYDKGDYIIREGEEGSTFFILAKGK VKVTQSTEGHDQPQLIKTLQ KGEYFGEKALISDDVRSANIIAEEN DVACLVIDRETFNQTVGTFEELQKY LEGYVANLNRDDEKRHAKRS MSNWKLSKALSLEMIQLKEKVARFS SSSPFQNLEIIATLGVGGFGRVELV KVKNENVAFAMKCIRKKHIV DTKQQEHVYSEKRILEELCSPFIVK LYRTFKDNKYVYMLLEACLGGELWS ILRDRGSFDEPTSKFCVACV TEAFDYLHRLGIIYRDLKPENLILD AEGYLKLVDFGFAKKIGSGQKTWTF CGTPEYVAPEVILNKGHDFS VDFWSLGILVYELLTGNPPFSGVDQ MMTYNLILKGIEKMDFPRKITRRPE DLIRRLCRQNPTERLGNLKN
  GINDIKKHRWLNGFNWEGLKARSLP SPLQRELKGPIDHSYFDKYPPEKGM PPDELSGWDKDFTRTRPLEQKLISE EDLAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome, Protein Kinase
• Protein Pathways: Gap junction, Long-term depression, Olfactory transduction

Gene Information

• Gene Name: PRKG2 protein kinase cGMP-dependent 2 [ Homo sapiens (human) ]
• Official Symbol: PRKG2
• Synonyms: AMD4; PKG2; SMDP; cGK2; cGKII; PRKGR2
• Gene ID: 5593
• mRNA Refseq: NM_006259.3
• Protein Refseq: NP_006250.1
• MIM: 601591
• UniProt ID: Q13237