Recombinant Full Length Human SCARB2 Protein, C-Flag-tagged

• Cat.No.: SCARB2-2073HFL
• Product Overview: Recombinant Full Length Human SCARB2 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: The protein encoded by this gene is a type III glycoprotein that is located primarily in limiting membranes of lysosomes and endosomes. Earlier studies in mice and rat suggested that this protein may participate in membrane transportation and the reorganization of endosomal/lysosomal compartment. The protein deficiency in mice was reported to impair cell membrane transport processes and cause pelvic junction obstruction, deafness, and peripheral neuropathy. Further studies in human showed that this protein is a ubiquitously expressed protein and that it is involved in the pathogenesis of HFMD (hand, foot, and mouth disease) caused by enterovirus-71 and possibly by coxsackievirus A16. Mutations in this gene caused an autosomal recessive progressive myoclonic epilepsy-4 (EPM4), also known as action myoclonus-renal failure syndrome (AMRF). Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 54.1 kDa
• AA Sequence: MGRCCFYTAGTLSLLLLVTSVTLLV ARVFQKAVDQSIEKKIVLRNGTEAF DSWEKPPLPVYTQFYFFNVT NPEEILRGETPRVEEVGPYTYRELR NKANIQFGDNGTTISAVSNKAYVFE RDQSVGDPKIDLIRTLNIPV LTVIEWSQVHFLREIIEAMLKAYQQ KLFVTHTVDELLWGYKDEILSLIHV FRPDISPYFGLFYEKNGTND GDYVFLTGEDSYLNFTKIVEWNGKT SLDWWITDKCNMINGTDGDSFHPLI TKDEVLYVFPSDFCRSVYIT FSDYESVQGLPAFRYKVPAEILANT SDNAGFCIPEGNCLGSGVLNVSICK NGAPIIMSFPHFYQADERFV SAIEGMHPNQEDHETFVDINPLTGI ILKAAKRFQINIYVKKLDDFVETGD IRTMVFPVMYLNESVHIDKE TASRLKSMINTTLIITNIPYIIMAL GVFFGLVFTWLACKGQGSMDEGTAD ERAPLIRT TRTRPLEQKLISEEDLAANDILDYK DDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Lysosome

Gene Information

• Gene Name: SCARB2 scavenger receptor class B member 2 [ Homo sapiens (human) ]
• Official Symbol: SCARB2
• Synonyms: AMRF; EPM4; LGP85; CD36L2; HLGP85; LIMP-2; LIMPII; SR-BII
• Gene ID: 950
• mRNA Refseq: NM_005506.4
• Protein Refseq: NP_005497.1
• MIM: 602257
• UniProt ID: Q14108