Recombinant Full Length Human SETD4 Protein, GST&His tagged

• Cat.No.: SETD4-998H
• Product Overview: Purified recombinant protein of Human SET domain containing 4 (SETD4), transcript variant 3, full length, with N-terminal GST and C-terminal HIS tag, expressed in E. coli.

Specification

• Species: Human
• Source: E.coli
• Tag: GST&His
• Protein Length: 1-440 aa
• Description: Histone-lysine N-methyltransferase that acts as a regulator of cell proliferation, cell differentiation and inflammatory response. Regulates the inflammatory response by mediating mono- and dimethylation of 'Lys-4' of histone H3 (H3K4me1 and H3K4me2, respectively), leading to activate the transcription of proinflammatory cytokines IL6 and TNF-alpha. Also involved in the regulation of stem cell quiescence by catalyzing the trimethylation of 'Lys-20' of histone H4 (H4K20me3), thereby promoting heterochromatin formation. Involved in proliferation, migration, paracrine and myogenic differentiation of bone marrow mesenchymal stem cells (BMSCs).
• Molecular Mass: 62.9 kDa
• Optimal pH: 0
• Isoelectric Point: 0
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Note: For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Storage Buffer: 25 mM Tris-HCl, pH 8.0, 150 mM NaCl, 1% sarkosyl, 10% glycerol
• Concentration: >0.05 μg/μL as determined by microplate BCA method
• Shipping: Dry Ice

Gene Information

• Gene Name: SETD4 SET domain containing 4 [ Homo sapiens (human) ]
• Official Symbol: SETD4
• Synonyms: SETD4; SET domain containing 4; C21orf18, C21orf27, chromosome 21 open reading frame 18 , chromosome 21 open reading frame 27; SET domain-containing protein 4; C21orf18; C21orf27
• Gene ID: 54093
• mRNA Refseq: NM_001007259
• Protein Refseq: NP_001007260
• MIM: 620995
• UniProt ID: Q9NVD3