Recombinant Full Length Human STING1 Protein, C-Flag-tagged

• Cat.No.: STING1-08HFL
• Product Overview: Recombinant Full Length Human STING1 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: This gene encodes a five transmembrane protein that functions as a major regulator of the innate immune response to viral and bacterial infections. The encoded protein is a pattern recognition receptor that detects cytosolic nucleic acids and transmits signals that activate type I interferon responses. The encoded protein has also been shown to play a role in apoptotic signaling by associating with type II major histocompatibility complex. Mutations in this gene are the cause of infantile-onset STING-associated vasculopathy. Alternate splicing results in multiple transcript variants.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 42 kDa
• AA Sequence: MPHSSLHPSIPCPRGHGAQKAALVL LSACLVTLWGLGEPPEHTLRYLVLH LASLQLGLLLNGVCSLAEEL RHIHSRYRGSYWRTVRACLGCPLRR GALLLLSIYFYYSLPNAVGPPFTWM LALLGLSQALNILLGLKGLA PAEISAVCEKGNFNVAHGLAWSYYI GYLRLILPELQARIRTYNQHYNNLL RGAVSQRLYILLPLDCGVPD NLSMADPNIRFLDKLPQQTGDHAGI KDRVYSNSIYELLENGQRAGTCVLE YATPLQTLFAMSQYSQAGFS REDRLEQAKLFCRTLEDILADAPES QNNCRLIAYQEPADDSSFSLSQEVL RHLRQEEKEEVTVGSLKTSA
  VPSTSTMSQEPELLISGMEKPLPLR TDFSTRTRPLEQKLISEEDLAANDI LDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Pathways: Cytosolic DNA-sensing pathway, RIG-I-like receptor signaling pathway

Gene Information

• Gene Name: STING1 stimulator of interferon response cGAMP interactor 1 [ Homo sapiens (human) ]
• Official Symbol: STING1
• Synonyms: ERIS; hMITA; hSTING; MITA; MPYS; NET23; SAVI; STING; STING-beta; TMEM173
• Gene ID: 340061
• mRNA Refseq: NM_198282.4
• Protein Refseq: NP_938023.1
• MIM: 612374
• UniProt ID: Q86WV6