Description : |
This gene belongs to a group of vacuolar protein sorting (VPS) genes. The encoded protein is a component of a large multimeric complex, termed the retromer complex, involved in retrograde transport of proteins from endosomes to the trans-Golgi network. The close structural similarity between the yeast and human proteins that make up this complex suggests a similarity in function. Expression studies in yeast and mammalian cells indicate that this protein interacts directly with VPS35, which serves as the core of the retromer complex. |
Source : |
In Vitro Cell Free System |
Species : |
Human |
Tag : |
GST |
Form : |
50 mM Tris-HCl, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. |
Molecular Mass : |
118.1 kDa |
Protein Length : |
796 amino acids |
AA Sequence : |
MPTTQQSPQDEQEKLLDEAIQAVKV QSFQMKRCLDKNKLMDALKHASNML GELRTSMLSPKSYYELYMAISDELH YLEVYLTDEFAKGRKVADLYELVQY AGNIIPRLYLLITVGVVYVKSFPQS RKDILKDLVEMCRGVQHPLRGLFLR NYLLQCTRNILPDEGEPTDEETTGD ISDSMDFVLLNFAEMNKLWVRMQHQ GHSRDREKRERERQELRILVGTNLV RLSQLEGVNVERYKQIVLTGILEQV VNCRDALAQEYLMECIIQVFPDEFH LQTLNPFLRACAELHQNVNVKNIII ALIDRLALFAHREDGPGIPADIKLF DIFSQQVATVIQSRQDMPSEDVVSL QVSLINLAMKCYPDRVDYVDKVLET TVEIFNKLNLEHIATSSAVSKELTR LLKIPVDTYNNILTVLKLKHFHPLF EYFDYESRKSMSCYVLSNVLDYNTE IVSQDQVDSIMNLVSTLIQDQPDQP VEDPDPEDFADEQSLVGRFIHLLRS EDPDQQYLILNTARKHFGAGGNQRI RFTLPPLVFAAYQLAFRYKENSKVD DKWEKKCQKIFSFAHQTISALIKAE LAELPLRLFLQGALAAGEIGFENHE TVAYEFMSQAFSLYEDEISDSKAQL AAITLIIGTFERMKCFSEENHEPLR TQCALAASKLLKKPDQGRAVSTCAH LFWSGRNTDKNGEELHGGKRVMECL KKALKIANQCMDPSLQVQLFIEILN RYIYFYEKENDAVTIQVLNQLIQKI REDLPNLESSEETEQINKHFHNTLE HLRLRRESPESEGPIYEGLIL |
Applications : |
Enzyme-linked Immunoabsorbent; Assay Western Blot (Recombinant protein); Antibody Production; Protein Array |
Notes : |
Best use within three months from the date of receipt of this protein. |
Storage : |
Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing. |