Recombinant Full Length Mouse MEN1 Protein, His&Avi tagged, Biotinylated

• Cat.No.: MEN1-5475MB
• Product Overview: Biotinylated recombinant Full Length Mouse MEN1 Protein with His&Avi tag was expressed in HEK293.

Specification

• Species: Mouse
• Source: HEK293
• Tag: Avi&His
• Protein Length: 1-611 aa
• Description: Enables DNA-binding transcription activator activity; chromatin binding activity; and transcription cis-regulatory region binding activity. Involved in transcription initiation-coupled chromatin remodeling. Acts upstream of or within several processes, including negative regulation of cell population proliferation; regulation of macromolecule metabolic process; and regulation of osteoblast differentiation. Located in chromosome, telomeric region; cytoplasm; and nucleus. Is expressed in several structures, including 1st branchial arch; alimentary system; central nervous system; gonad; and sensory organ. Used to study growth hormone secreting pituitary adenoma; hyperparathyroidism; multiple endocrine neoplasia type 1; and prolactinoma. Human ortholog(s) of this gene implicated in endocrine gland cancer (multiple); hyperparathyroidism; and multiple endocrine neoplasia type 1. Orthologous to human MEN1 (menin 1).
• Molecular Mass: 71 kDa
• AASequence: MGLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYQDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLETGEERTGEQAQGTQGQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVHIVSREAEAAEAEEPWGDEAREGRRRGPRRESKPEEPPPPKKPALDKGPGSGQSAGSGPPRKTSGTVPGTTRGGQEVGNAAQAPAPAASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGLHHHHHHHHHHGLNDIFEAQKIEWHE
• Endotoxin: <1EU/μg by LAL
• Purity: > 85% by SDS-PAGE
• Labeling efficiency: 0.93 by HABA
• Storage: Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Storage Buffer: Sterile PBS, pH7.4
• Concentration: 0.24 mg/mL by BCA
• Conjugation: Biotin

Gene Information

• Gene Name: Men1 multiple endocrine neoplasia 1 [ Mus musculus (house mouse) ]
• Official Symbol: Men1
• Synonyms: Men1; multiple endocrine neoplasia 1; menin
• Gene ID: 17283
• mRNA Refseq: NM_008583
• Protein Refseq: NP_032609
• UniProt ID: F8WHD9