Recombinant Full Length Probable 4-Amino-4-Deoxy-L-Arabinose-Phosphoundecaprenol Flippase Subunit Arne(Arne) Protein, His-Tagged
Cat.No. : | RFL27556EF |
Product Overview : | Recombinant Full Length Probable 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE(arnE) Protein (Q8X4J8) (1-111aa), fused to N-terminal His tag, was expressed in E. coli. |
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Source : | E.coli expression system |
Species : | Escherichia coli O157:H7 |
Tag : | His |
Form : | Lyophilized powder |
Protein Length : | Full Length (1-111) |
AA Sequence : | MIWLTLVFASLLSVAGQLCQKQATC FVAISKRRKHIVLWLGLALACLGLA MVLWLLVLQN VPVGIAYPMLSLNFVWVTLAAVKLW HEPVSPRHWCGVAFIIGGIVILGST V |
Purity : | Greater than 90% as determined by SDS-PAGE. |
Notes : | Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week. |
Storage : | Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles. |
Storage Buffer : | Tris/PBS-based buffer, 6% Trehalose, pH 8.0 |
Reconstitution : | We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference. |
Gene Name : | arnE |
Synonyms : | arnE; Z3516; ECs3145.1; Probable 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; L-Ara4N-phosphoundecaprenol flippase subunit ArnE; Undecaprenyl phosphate-aminoarabinose flippase subunit ArnE |
UniProt ID : | Q8X4J8 |
Gene Name : | arnE |
Synonyms : | arnE; Z3516; ECs3145.1; Probable 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; L-Ara4N-phosphoundecaprenol flippase subunit ArnE; Undecaprenyl phosphate-aminoarabinose flippase subunit ArnE |
UniProt ID : | Q8X4J8 |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (10)
Ask a questionThe potential therapeutic targeting of ARNE protein has not been extensively explored. However, given its critical role in intracellular trafficking, it is possible that modulation of ARNE activity could have therapeutic implications in diseases associated with defects in vesicle transport or protein secretion.
ARNE protein primarily interacts with Arf1, but it may also have the potential to interact with other guanine nucleotide exchange factors involved in vesicle trafficking pathways. Further studies are required to comprehensively understand the extent of these interactions.
Yes, ARNE protein interacts with Arf1, its substrate, to facilitate the activation of Arf1 and vesicle formation. It also interacts with various other proteins involved in vesicle trafficking, such as coat proteins and adapter proteins.
As of now, there are no specific drugs or compounds known to directly target ARNE protein activity. However, the importance of intracellular trafficking in various diseases has prompted research into small molecules and therapeutic strategies that can modulate general vesicle trafficking processes, which indirectly impact ARNE protein function.
Yes, ARNE protein is conserved across different species, including mammals, suggesting its fundamental importance in cellular processes involved in intracellular trafficking.
Currently, there is limited information on specific diseases or conditions directly linked to ARNE protein dysfunction. However, dysregulation of intracellular trafficking processes, which involve ARNE protein, can contribute to various pathological conditions, including neurodevelopmental disorders and cancer.
While ARNE protein's role in neuronal function is not extensively studied, correct vesicle trafficking and membrane organization are crucial for proper neuronal function and synaptic transmission. Thus, it is plausible that ARNE protein may play a role in neuronal processes, but further research is necessary to elucidate its specific contributions.
ARNE protein is involved in various cellular processes, including protein trafficking, vesicle formation, membrane remodeling, and cargo selection. It plays a crucial role in regulating the dynamics of intracellular membrane compartments such as the Golgi apparatus and endosomes.
Although ARNE protein is not essential for cell viability, it plays a critical role in regulating intracellular trafficking and vesicle transport. Disruption of ARNE function can lead to defects in protein secretion, membrane organization, and overall cellular homeostasis.
While the direct association between ARNE protein and cancer has not been extensively studied, dysregulation of intracellular trafficking and vesicle transport pathways can contribute to cancer development and progression. As ARNE protein is involved in these processes, it is possible that perturbations in its function could have implications in cancer biology. Further research is needed to explore this potential link.
Customer Reviews (6)
Write a reviewIts versatility and reliability make it a great choice for researchers exploring protein dynamics, function, and interactions.
the manufacturer's support team provides extensive technical assistance, helping researchers navigate any challenges they may face throughout their experiments.
The manufacturer's commitment to delivering a high-quality product further enhances its reputation and guarantees its suitability for a wide range of research applications.
The arnE protein is of exceptional quality, making it an ideal choice to meet my experimental requirements.
researchers using thearnE protein can benefit from its high purity and quality, ensuring reliable results.
Its consistent and accurate results, combined with its compatibility with various cutting-edge techniques, ensure that data collection and analysis are both reliable and meaningful.
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