"slo" Related Products

Recombinant Hemolytic streptococcus Streptolysin O

Cat.No.: slo-001S
Product Overview: The product was highly purified from E.coli over-expressing SLO of Group C hemolytic streptococci.
Description: Streptolysin O (SLO) is a membrane-damaging extracellular toxin produced by hemolytic streptococci. The membrane-damaging activity is measured by hemolysis of red-blood cells. SLO is easily inactivated in the presence of oxygen but can be reactivated by thiol compounds, so it is also called thiol-activated cytolysin. SLO is produced not only by Group A hemolytic streptococci but also by Group C and Group G strains. The amino acid sequences are highly conserved among them and their homology is over 98%.
Source: E. coli
Species: Hemolytic streptococcus
Form: 1 mg/ml in PBS (-), 1 mM DTT, 50% glycerol, sterilized by filtration
Bio-activity: The specific activity is as high as 1,900,000 hemolytic units (HU) /mg and the product forms a big hole on the cell membrane, which enables the introduction of protein inside the cells in vivo.
AA Sequence: NKQNTANTETTTTNEQPKPESSELTTEKAGQKMDDMLNSNDMIKLAPKEMPLESAEKEEKKSEDNKKSEEDHTEEINDKIYSLNYNELEVLAKNGETIENFVPKEGVKKADKFIVIERKKKNINTTPVDISIIDSVTDRTYPAALQLANKGFTENKPDAVVTKRNPQKIHIDLPGMGDKATVEVNDPTYANVSTAIDNLVNQWHDNYSGGNTLPARTQYTESMVYSKSQIEAALNVNSKILDGTLGIDFKSISKGEKKVMIAAYKQIFYTVSANLPNNPADVFDKSVTLKELQRKGVSNEAPPLFVSNVAYGRTVFVKLETSSKSNDVEAAFSAALKGTDVKTNGKYSDILENSSFTAVVLGGDAAEHNKVVTKDFDVIRNVIKDNATFSRKNPAYPISYTSVFLKNNKIAGVNNRSEYVETTSTEYTSGKINLSHQGAYVAQYEILWDEINYDDKGKEVITKRRWDNNWYSKTSPFSTVIPLGANSRNIRIMARECTGLAWEWWRKVIDERDVKLSKEINVNISGSTLSPYGSITYK
Purity: Over 98% by SDS-PAGE
Unit Definition: Definition of 1HU is activation of 50% hemolysis by incubating 3% sheep red blood cells at 37centigrade for 30 min.
Applications: 1).Antigen for the measurement of anti-streptolysin O antibody (ASO) (diagnostic reagent).
2).Reagent for membrane pore formation to introduce small-to-macromolecules into living cells.
Notes: Inactivated SLO can be reactivated by thiol reagents such as 20 mM cysteine or 10 mM DTT.
Storage: Store at -20 centigrade(long period, -70 centigrade).
Warning: Handling and storage precautions: Biohazard. Do not use if skin is cut or scratched.
Other precautions: Substance not yet fully tested.
Protective gloves: compatible chemical-resistant gloves.
Eye protection: ansi approved chemical workers goggle.
Other protective equipment: eye wash and deluge shower meeting ansi design criteria. Work hygienic practices: wash thoroughly after handling.
Gene Name: Streptolysin O precursor [Streptococcus pyogenes M1 GAS]
Official Symbol: slo
Synonyms: Streptolysin O; slo
Gene ID: 900490
Protein Refseq: NP_268546.1
UniProt ID: Q54114

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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