| Species : |
HPV16 |
| Source : |
E.coli |
| Tag : |
His |
| Description : |
Minor protein of the capsid that localizes along the inner surface of the virion, within the central cavities beneath the L1 pentamers. Plays a role in capsid stabilization through interaction with the major capsid protein L1. Once the virion enters the host cell, L2 escorts the genomic DNA into the nucleus by promoting escape from the endosomal compartments and traffic through the host Golgi network. Plays a role through its interaction with host dynein in the intracellular microtubule-dependent transport of viral capsid toward the nucleus. Mediates the viral genome import into the nucleus through binding to host importins. Once within the nucleus, L2 localizes viral genomes to host PML bodies in order to activate early gene expression for establishment of infection. Later on, promotes late gene expression by interacting with the viral E2 protein and by inhibiting its transcriptional activation functions. During virion assembly, encapsidates the genome by direct interaction with the viral DNA. |
| Purity : |
>95% , based on SDS-PAGE. |
| Applications : |
WB standard, antibody ELISA, immunogen, etc. |
| Notes : |
For research use only, not for use in diagnostic procedures. |
| Storage : |
Keep it at 4 centigrade if used within a month. For long term storage, split it into small aliquots and keep at -80 centigrade. Avoid repeated freezing and thawing. The product will be expired one year after receiving if stored properly. Non-hazardous. No MSDS required. |
| Storage Buffer : |
Each vial contains 100 μg of protein in PBS with 8M Urea. |
