Recombinant HRSV G protein, His-tagged

• Cat.No.: G-99V
• Product Overview: Recombinant HRSV G protein(His 67 - Arg 297) fused with His tag at C-terminal was expressed in HEK293.

Specification

• Description: Human respiratory syncytial virus (HRSV) is the most common etiological agent of acute lower respiratory tract disease in infants and can cause repeated infections throughout life. Human respiratory syncytial virus A (strain Long) major surface glycoprotein G (RSV-G), a member of the pneumoviruses glycoprotein G family, is also known as attachment glycoprotein G and membrane-bound glycoprotein (mG), which contains a linear heparin binding domain essential for virus attachment to the host. Concretely speaking, RSV-G can attache the virion to the host cell membrane by interacting with heparan sulfate, initiating the infection. Furthermore, RSV-G can also interact with host CX3CR1, the receptor for the CX3C chemokine fractalkine, to modulate the immune response and facilitate infection. Unlike the other paramyxovirus attachment proteins, RSV-G lacks both neuraminidase and hemagglutinating activities.
• Source: HEK293
• Species: HRSV
• Tag: His
• Predicted N Terminal: His 67
• Form: Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally Mannitol or Trehalose are added as protectants before lyophilization.
• Molecular Mass: Has a calculated MW of 26.2 kDa. DTT-reduced Protein migrates as 60-94 kDa in SDS-PAGE due to glycosylation.
• Protein length: His 67 - Arg 297
• Endotoxin: Less than 1.0 EU per μg of the rh RSV-G by the LAL method.
• Purity: >90% as determined by SDS-PAGE.
• Storage: Avoid repeated freeze-thaw cycles.
  No activity loss was observed after storage at:
  In lyophilized state for 1 year (4 centigrade); After reconstitution under sterile conditions for 3 months (-70 centigrade).

Gene Information

• Gene Name: G G [ Human respiratory syncytial virus ]
• Official Symbol: G
• Synonyms: G; attachment glycoprotein
• Gene ID: 1489824
• Protein Refseq: NP_056862
• UniProt ID: O36633