| Description : |
The protein encoded by this gene is a protease inhibitor and cytokine transporter. It uses a bait-and-trap mechanism to inhibit a broad spectrum of proteases, including trypsin, thrombin and collagenase. It can also inhibit inflammatory cytokines, and it thus disrupts inflammatory cascades. Mutations in this gene are a cause of alpha-2-macroglobulin deficiency. This gene is implicated in Alzheimer's disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. A related pseudogene, which is also located on the p arm of chromosome 12, has been identified. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
163.3 kDa |
| AA Sequence : |
MGKNKLLHPSLVLLLLVLLPTDASV SGKPQYMVLVPSLLHTETTEKGCVL LSYLNETVTVSASLESVRGNRSLFT DLEAENDVLHCVAFAVPKSSSNEEV MFLTVQVKGPTQEFKKRTTVMVKNE DSLVFVQTDKSIYKPGQTVKFRVVS MDENFHPLNELIPLVYIQDPKGNRI AQWQSFQLEGGLKQFSFPLSSEPFQ GSYKVVVQKKSGGRTEHPFTVEEFV LPKFEVQVTVPKIITILEEEMNVSV CGLYTYGKPVPGHVTVSICRKYSDA SDCHGEDSQAFCEKFSGQLNSHGCF YQQVKTKVFQLKRKEYEMKLHTEAQ IQEEGTVVELTGRQSSEITRTITKL SFVKVDSHFRQGIPFFGQVRLVDGK GVPIPNKVIFIRGNEANYYSNATTD EHGLVQFSINTTNVMGTSLTVRVNY KDRSPCYGYQWVSEEHEEAHHTAYL VFSPSKSFVHLEPMSHELPCGHTQT VQAHYILNGGTLLGLKKLSFYYLIM AKGGIVRTGTHGLLVKQEDMKGHFS ISIPVKSDIAPVARLLIYAVLPTGD VIGDSAKYDVENCLANKVDLSFSPS QSLPASHAHLRVTAAPQSVCALRAV DQSVLLMKPDAELSASSVYNLLPEK DLTGFPGPLNDQDDEDCINRHNVYI NGITYTPVSSTNEKDMYSFLEDMGL KAFTNSKIRKPKMCPQLQQYEMHGP EGLRVGFYESDVMGRGHARLVHVEE PHTETVRKYFPETWIWDLVVVNSAG VAEVGVTVPDTITEWKAGAFCLSED AGLGISSTASLRAFQPFFVELTMPY SVIRGEAFTLKATVLNYLPKCIRVS VQLEASPAFLAVPVEKEQAPHCICA NGRQTVSWAVTPKSLGNVNFTVSAE ALESQELCGTEVPSVPEHGRKDTVI KPLLVEPEGLEKETTFNSLLCPSGG EVSEELSLKLPPNVVEESARASVSV LGDILGSAMQNTQNLLQMPYGCGEQ NMVLFAPNIYVLDYLNETQQLTPEV KSKAIGYLNTGYQRQLNYKHYDGSY STFGERYGRNQGNTWLTAFVLKTFA QARAYIFIDEAHITQALIWLSQRQK DNGCFRSSGSLLNNAIKGGVEDEVT LSAYITIALLEIPLTVTHPVVRNAL FCLESAWKTAQEGDHGSHVYTKALL AYAFALAGNQDKRKEVLKSLNEEAV KKDNSVHWERPQKPKAPVGHFYEPQ APSAEVEMTSYVLLAYLTAQPAPTS EDLTSATNIVKWITKQQNAQGGFSS TQDTVVALHALSKYGAATFTRTGKA AQVTIQSSGTFSSKFQVDNNNRLLL QQVSLPELPGEYSMKVTGEGCVYLQ TSLKYNILPEKEEFPFALGVQTLPQ TCDEPKAHTSFQISLSVSYTGSRSA SNMAIVDVKMVSGFIPLKPTVKMLE RSNHVSRTEVSSNHVLIYLDKVSNQ TLSLFFTVLQDVPVRDLKPAIVKVY DYYETDEFAIAEYNAPCSKDLGNAT RTRPLEQKLISEEDLAANDILDYKD DDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
