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Recombinant Human ACADSB Protein, GST-Tagged

Cat.No. : ACADSB-137H
Product Overview : Human ACADSB full-length ORF ( AAH13756.1, 1 a.a. - 432 a.a.) recombinant protein with GST-tag at N-terminal.
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Description : Short/branched chain acyl-CoA dehydrogenase(ACADSB) is a member of the acyl-CoA dehydrogenase family of enzymes that catalyze the dehydrogenation of acyl-CoA derivatives in the metabolism of fatty acids or branch chained amino acids. Substrate specificity is the primary characteristic used to define members of this gene family. The ACADSB gene product has the greatest activity towards the short branched chain acyl-CoA derivative, (S)-2-methylbutyryl-CoA, but also reacts significantly with other 2-methyl branched chain substrates and with short straight chain acyl-CoAs. The cDNA encodes for a mitochondrial precursor protein which is cleaved upon mitochondrial import and predicted to yield a mature peptide of approximately 43.7-KDa. [provided by RefSeq, Jul 2008]
Source : Wheat Germ
Species : Human
Tag : GST
Molecular Mass : 95.5 kDa
AA Sequence : MSGCGLFLRTTAAARACRGLVVSTA NRRLLRTSPPVRAFAKELFLGKIKK KEVFPFPEVSQDELNEINQFLGPVE KFFTEEVDSRKIDQEGKIPDETLEK LKSLGLFGLQVPEEYGGLGFSNTMY SRLGEIISMDGSITVTLAAHQAIGL KGIILAGTEEQKAKYLPKLASGEHI AAFCLTEPASGSDAASIRSRATLSE DKKHYILNGSKVWITNGGLANIFTV FAKTEVVDSDGSVKDKITAFIVERD FGGVTNGKPEDKLGIRGSNTCEVHF ENTKIPVENILGEVGDGFKVAMNIL NSGRFSMGSVVAGLLKRLIEMTAEY ACTRKQFNKRLSEFGLIQEKFALMA QKAYVMESMTYLTAGMLDQPGFPDC SIEAAMVKVFSSEAAWQCVSEALQI LGGLGYTRDYPYERILRDTRILLIF EGTNEILRMYIALTGLQHAGRILTT RIHELKQAKVSTVMDTVGRRLRDSL GRTVDLGLTGNHGVVHPSLADSANK FEENTYCFGRTVETLLLRFGKTIME EQLVLKRVANILINLYGMTAVLSRA SRSIRIGLRNHDHEVLLANTFCVEA YLQNLFSLSQLDKYAPENLDEQIKK VSQQILEKRAYICAHPLDRTC
Applications : Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
Notes : Best use within three months from the date of receipt of this protein.
Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
Storage Buffer : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Gene Name : ACADSB acyl-CoA dehydrogenase, short/branched chain [ Homo sapiens ]
Official Symbol : ACADSB
Synonyms : ACADSB; acyl-CoA dehydrogenase, short/branched chain; ACAD7; SBCAD; 2-MEBCAD; short/branched chain specific acyl-CoA dehydrogenase, mitochondrial; 2-methylbutyryl-coenzyme A dehydrogenase; 2-methyl branched chain acyl-CoA dehydrogenase; 2 MEBCAD; 2 methyl branched chain acyl CoA dehydrogenase; 2 methylbutyryl CoA dehydrogenase; 2-methylbutyryl-CoA dehydrogenase; ACDSB_HUMAN; acyl CoA dehydrogenase, short/branched chain; OTTHUMP00000020685; OTTHUMP00000046795; Short/branched chain specific acyl-CoA dehydrogenase; acyl-Coenzyme A dehydrogenase, short/branched chain; 2-methylbutyryl-coenzyme A dehydrogenase; short/branched chain specific acyl-CoA dehydrogenase, mitochondrial; EC 1.3.99
Gene ID : 36
mRNA Refseq : NM_001609
Protein Refseq : NP_001600
MIM : 600301
UniProt ID : P45954

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (10)

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How does the activity of this protein contribute to cellular metabolism? 11/10/2022

The activity of acyl-CoA dehydrogenase short/branched chain contributes to the breakdown of branched-chain amino acids and fatty acids to produce energy in cells.

Where is acyl-CoA dehydrogenase short/branched chain protein located within the cell? 08/29/2022

Acyl-CoA dehydrogenase short/branched chain protein is located in the mitochondrial matrix.

What is the substrate specificity of this protein? 05/01/2022

Acyl-CoA dehydrogenase short/branched chain protein has specificity for short/branched chain fatty acyl-CoA substrates.

What diseases or disorders are associated with mutations in this protein? 02/05/2020

Mutations in this protein are associated with a variety of metabolic disorders, including isovaleric acidemia and 2-methylbutyryl-CoA dehydrogenase deficiency.

Are there any known inhibitors or activators of this protein? 06/05/2019

There are currently no known inhibitors or activators of acyl-CoA dehydrogenase short/branched chain protein.

What are the physiological roles of acyl-CoA dehydrogenase short/branched chain? 05/21/2019

Acyl-CoA dehydrogenase short/branched chain plays a key role in energy metabolism and the catabolism of branched-chain amino acids in cells.

What is the structure of this protein and how does it relate to its function? 02/02/2018

Acyl-CoA dehydrogenase short/branched chain protein has a flavin adenine dinucleotide (FAD)-binding domain that is essential for its function.

How is the expression of acyl-CoA dehydrogenase short/branched chain regulated? 01/24/2017

The expression of acyl-CoA dehydrogenase short/branched chain is regulated by a variety of factors, including gene expression and protein degradation pathways.

What research is currently being conducted to further understand the function of acyl-CoA dehydrogenase short/branched chain protein? 01/27/2016

Research is ongoing to further understand the function and regulation of acyl-CoA dehydrogenase short/branched chain protein, as well as its role in metabolic disorders.

What is the function of acyl-CoA dehydrogenase short/branched chain protein? 08/06/2015

Acyl-CoA dehydrogenase short/branched chain protein is involved in the metabolism of branched-chain amino acids and fatty acids.

Customer Reviews (2)

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Reviews
05/07/2020

    Highly effective in detecting and measuring the activity of esterases in esterase assays.

    04/02/2018

      Demonstrates excellent specificity and sensitivity in detecting the target protein in fluorescence-based assays.

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