Recombinant Human ACADVL Protein, GST-Tagged

• Cat.No.: ACADVL-139H
• Product Overview: Human ACADVL partial ORF ( NP_000009, 345 a.a. - 434 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: The protein encoded by this gene is targeted to the inner mitochondrial membrane where it catalyzes the first step of the mitochondrial fatty acid beta-oxidation pathway. This acyl-Coenzyme A dehydrogenase is specific to long-chain and very-long-chain fatty acids. A deficiency in this gene product reduces myocardial fatty acid beta-oxidation and is associated with cardiomyopathy. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 95.6 kDa
• AA Sequence: MSGCGLFLRTTAAARACRGLVVSTA NRRLLRTSPPVRAFAKELFLGKIKK KEVFPFPEVSQDELNEINQFLGPVE KFFTEEVDSRKIDQEGKIPDETLEK LKSLGLFGLQVPEEYGGLGFSNTMY SRLGEIISMDGSITVTLAAHQAIGL KGIILAGTEEQKAKYLPKLASGEHI AAFCLTEPASGSDAASIRSRATLSE DKKHYILNGSKVWITNGGLANIFTV FAKTEVVDSDGSVKDKITAFIVERD FGGVTNGKPEDKLGIRGSNTCEVHF ENTKIPVENILGEVGDGFKVAMNIL NSGRFSMGSVVAGLLKRLIEMTAEY ACTRKQFNKRLSEFGLIQEKFALMA QKAYVMESMTYLTAGMLDQPGFPDC SIEAAMVKVFSSEAAWQCVSEALQI LGGLGYTRDYPYERILRDTRILLIF EGTNEILRMYIALTGLQHAGRILTT RIHELKQAKVSTVMDTVGRRLRDSL GRTVDLGLTGNHGVVHPSLADSANK FEENTYCFGRTVETLLLRFGKTIME EQLVLKRVANILINLYGMTAVLSRA SRSIRIGLRNHDHEVLLANTFCVEA YLQNLFSLSQLDKYAPENLDEQIKK VSQQILEKRAYICAHPLDRTC
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: ACADVL acyl-CoA dehydrogenase, very long chain [ Homo sapiens ]
• Official Symbol: ACADVL
• Synonyms: ACADVL; acyl-CoA dehydrogenase, very long chain; acyl Coenzyme A dehydrogenase, very long chain; very long-chain specific acyl-CoA dehydrogenase, mitochondrial; ACAD6; LCACD; VLCAD; acyl-Coenzyme A dehydrogenase, very long chain
• Gene ID: 37
• mRNA Refseq: NM_000018
• Protein Refseq: NP_000009
• MIM: 609575
• UniProt ID: P49748

Reviews

09/15/2022

I was very impressed with the customized recombinant protein that Creative BioMart created for me. The technical support experts were extremely helpful and accommodating, and the product exceeded my expectations.

05/08/2021

I have been consistently impressed with the quality and purity of Creative BioMart's recombinant ACADVL proteins. Their products are reliable and cost-effective, and I plan to repurchase from them in the future.

01/16/2020

Thanks to Creative BioMart's ACADVL recombinant protein, I was able to save a significant amount of time on my project. The product was of high quality and reasonably priced.

Q&As

What are the applications of the recombinant ACADVL protein?

The recombinant ACADVL protein can be used in various applications, such as enzyme assays, drug screening, and protein-protein interaction studies.

What are the recommended usage guidelines of your recombinant ACADVL protein?

The recommended usage guidelines can vary depending on the specific application, but typically involve optimizing the protein concentration, buffer conditions, and other experimental parameters.

Can your recombinant ACADVL protein be used in biomarker research?

Sure, ACADVL has been suggested as a potential biomarker for various diseases, including non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes.

What diseases can be caused by abnormal expression of ACADVL?

ACADVL deficiency reduces myocardial fatty acid β-oxidation and is associated with cardiomyopathy. In addition, very long-chain acyl-CoA dehydrogenase deficiency is a rare, life-threatening disorder of mitochondrial fatty acid oxidation metabolism caused by mutations in the ACADVL gene.

How is ACADVL implicated in disease, and what are some potential therapeutic targets?

Mutations in the ACADVL gene can lead to VLCADD, a rare inherited disorder that affects the metabolism of VLCFAs. Symptoms of VLCADD can include muscle weakness, lethargy, and hypoglycemia. A recent study investigated the impact of ACADVL deficiency on mitochondrial function and found that it leads to impaired fatty acid oxidation and increased oxidative stress.

What quality control measures are in place to ensure the recombinant ACADVL protein is of high quality?

These quality control measures can include testing for purity, concentration, and functionality, as well as ensuring the protein is free from contaminants, such as endotoxins or microbial contaminants.

Can you customize recombinant proteins with potential hotspot ACADVL mutations?

Sure, you can describe the specific mutation site in the online form, and our scientists will tailor the corresponding protein products for you.

What is the role of ACADVL in lipid metabolism?

ACADVL has been implicated in several lipid metabolic pathways, including the beta-oxidation of fatty acids, the biosynthesis of unsaturated fatty acids, and the synthesis of ether lipids.

Do you have commercial antibodies for ACADVL?

You can submit specific requirements, and our experts will contact you.

Can your recombinant ACADVL protein be used for structural studies?

Our high-purity recombinant proteins are suitable for biophysics-related research, such as structural elucidation, molecular dynamics simulations, and interaction studies.