Recombinant Human ACKR2 Protein

• Cat.No.: ACKR2-0495H
• Product Overview: Human ACKR2 full-length ORF (NP_001287.2) recombinant protein without tag.

Specification

• Description: This gene encodes a beta chemokine receptor, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptor-mediated signal transduction are critical for the recruitment of effector immune cells to the inflammation site. This gene is expressed in a range of tissues and hemopoietic cells. The expression of this receptor in lymphatic endothelial cells and overexpression in vascular tumors suggested its function in chemokine-driven recirculation of leukocytes and possible chemokine effects on the development and growth of vascular tumors. This receptor appears to bind the majority of beta-chemokine family members; however, its specific function remains unknown. This gene is mapped to chromosome 3p21.3, a region that includes a cluster of chemokine receptor genes. [provided by RefSeq, Jul 2008]
• Source: Wheat Germ
• Species: Human
• Form: Liquid
• Molecular Mass: 43.4 kDa
• AA Sequence: MAATASPQPLATEDADSENSSFYYY DYLDEVAFMLCRKDAVVSFGKVFLP VFYSLIFVLGLSGNLLLLMVLLRYV PRRRMVEIYLLNLAISNLLFLVTLP FWGISVAWHWVFGSFLCKMVSTLYT INFYSGIFFISCMSLDKYLEIVHAQ PYHRLRTRAKSLLLATIVWAVSLAV SIPDMVFVQTHENPKGVWNCHADFG GHGTIWKLFLRFQQNLLGFLLPLLA MIFFYSRIGCVLVRLRPAGQGRALK IAAALVVAFFVLWFPYNLTLFLHTL LDLQVFGNCEVSQHLDYALQVTESI AFLHCCFSPILYAFSSHRFRQYLKA FLAAVLGWHLAPGTAQASLSSCSES SILTAQEEMTGMNDLGERQSENYPN KEDVGNKSA
• Applications: Antibody Production
  Functional Study
  Compound Screening
• Usage: Heating may cause protein aggregation. Please do not heat this product before electrophoresis.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 25 mM Tris-HCl of pH8.0 containing 2% glycerol.

Gene Information

• Gene Name: ACKR2 atypical chemokine receptor 2 [ Homo sapiens (human) ]
• Official Symbol: ACKR2
• Synonyms: ACKR2; atypical chemokine receptor 2; CCBP2; chemokine binding protein 2; CMKBR9; chemokine-binding protein 2; CCR9; CCR10; D6; chemokine receptor D6; chemokine receptor CCR-9; C-C chemokine receptor D6; chemokine receptor CCR-10; chemokine (C-C) receptor 9; chemokine-binding protein D6; chemokine (C-C motif) receptor 9; CC-chemokine-binding receptor JAB61; hD6; MGC126678; MGC138250
• Gene ID: 1238
• mRNA Refseq: NM_001296
• Protein Refseq: NP_001287
• MIM: 602648
• UniProt ID: O00590