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Recombinant Human ACTL7A Protein (1-435 aa), His-SUMO-tagged

Cat.No. : ACTL7A-1169H
Product Overview : Recombinant Human ACTL7A Protein (1-435 aa) is produced by E. coli expression system. This protein is fused with a 6xHis-SUMO tag at the N-terminal. Research Area: Signal Transduction. Protein Description: Full Length.
  • Specification
  • Gene Information
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Source : E. coli
Species : Human
Tag : His-SUMO
Form : Tris-based buffer,50% glycerol
Molecular Mass : 64.6 kDa
Protein length : 1-435 aa
AA Sequence : MWAPPAAIMGDGPTKKVGNQAPLQT QALQTASLRDGPAKRAVWVRHTSSE PQEPTESKAAKERPKQEVTKAVVVD LGTGYCKCGFAGLPRPTHKISTTVG KPYMETAKTGDNRKETFVGQELNNT NVHLKLVNPLRHGIIVDWDTVQDIW EYLFRQEMKIAPEEHAVLVSDPPLS PHTNREKYAEMLFEAFNTPAMHIAY QSRLSMYSYGRTSGLVVEVGHGVSY VVPIYEGYPLPSITGRLDYAGSDLT AYLLGLLNSAGNEFTQDQMGIVEDI KKKCCFVALDPIEEKKVPLSEHTIR YVLPDGKEIQLCQERFLCSEMFFKP SLIKSMQLGLHTQTVSCLNKCDIAL KRDLMGNILLCGGSTMLSGFPNRLQ KELSSMCPNDTPQVNVLPERDSAVW TGGSILASLQGFQPLWVHRFEYEEH GPFFLYRRCF
Purity : > 90% as determined by SDS-PAGE.
Notes : Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week.
Storage : The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade.
Concentration : A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
Gene Name : ACTL7A actin-like 7A [ Homo sapiens ]
Official Symbol : ACTL7A
Synonyms : ACTL7A; actin-like 7A; actin-like protein 7A;
Gene ID : 10881
mRNA Refseq : NM_006687
Protein Refseq : NP_006678
MIM : 604303
UniProt ID : Q9Y615

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (20)

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How might the altered localization of ZPBP in Actl7a KO mice affect sperm-zona pellucida binding ability? 11/03/2022

The altered localization of ZPBP in Actl7a KO mice suggests a potential impact on sperm-zona pellucida binding ability.

How does Actl7a deficiency contribute to male infertility? 07/29/2022

Actl7a deficiency affects the localization of ZPBP, potentially impacting sperm-zona pellucida binding. It also leads to abnormalities in PLCZ1 localization and expression, resulting in reduced calcium oscillations in oocytes.

Where is ACTL7A found in the human body? 10/17/2021

ACTL7A is found in various tissues, including the brain, heart, liver, and skeletal muscle.

Can ACTL7A expression be regulated? 07/09/2021

Yes, ACTL7A expression can be regulated by various factors, including signaling pathways and transcription factors.

Does ACTL7A have any known paralogs or similar genes? 10/09/2020

Yes, ACTL7B is a paralog of ACTL7A, sharing sequence similarities and similar functions in chromatin remodeling.

What is the molecular function of ACTL7A? 08/26/2020

ACTL7A is involved in nucleosome assembly, histone binding, and ATP-dependent chromatin remodeling.

What do findings suggest about Actl7a and male infertility? 12/18/2019

It revearls the importance of ACTL7A in the complex processes involved in fertilization.

What condition is associated with Actl7a deficiency? 06/12/2019

Actl7a deficiency is linked to male infertility.

What is the consequence of the abnormal localization and expression of PLCZ1? 06/30/2018

The abnormal localization and expression of PLCZ1 resulted in reduced calcium oscillations in oocytes.

What are the known interactions of ACTL7A? 06/19/2018

ACTL7A interacts with other proteins involved in chromatin remodeling, such as SMARCA4 and SMARCA2.

Is there any research on the role of ACTL7A in neurodevelopmental disorders? 05/30/2018

Yes, studies have shown that ACTL7A mutations can contribute to neurodevelopmental disorders, and further research is being conducted in this area.

Is ACTL7A associated with cancer? 04/27/2018

There is currently no significant evidence linking ACTL7A to cancer development or progression.

 What was found regarding the localization of ZPBP in Actl7a homozygous KO male mice? 04/06/2018

The localization of ZPBP was found to be altered in the sperm of Actl7a homozygous KO male mice.

Can ACTL7A be a potential therapeutic target? 03/25/2018

While ACTL7A itself is not currently considered a therapeutic target, understanding its role in chromatin remodeling could have implications for future therapeutic interventions.

Are there any genetic disorders associated with ACTL7A mutations? 02/10/2018

Yes, mutations in ACTL7A have been linked to developmental disorders, including intellectual disability and autism spectrum disorder.

What is the relationship between ACTL7A and ZPBP? 09/21/2017

ACTL7A and ZPBP can form a complex that is potentially involved in acrosomal formation.

What will happen if ACTL7A undergoes a mutation? 05/27/2017

Mutations in the Actl7a gene have been reported to lead to male infertility

What is ACTL7A? 06/10/2016

ACTL7A plays a role in chromatin remodeling and gene transcription regulation.

What abnormalities were observed in the localization and expression of the PLCZ1 protein? 02/20/2016

Further studies revealed that the localization and expression of the PLCZ1 protein were abnormal in misshapen sperm.

Is ACTL7A involved in any specific biological processes? 01/02/2016

Yes, ACTL7A is involved in processes such as transcriptional regulation, DNA repair, and neuronal development.

Customer Reviews (5)

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Reviews
02/05/2020

    The company's customer support team is highly knowledgeable and responsive, readily available to address any technical or product-related queries.

    03/13/2019

      In our experiments, the protein product consistently exhibits robust and dose-dependent effects, leading to significant changes in the desired cellular responses.

      01/22/2019

        Each batch of the protein product shows minimal batch-to-batch variation, providing consistent results and reducing experimental variability.

        04/29/2018

          The protein product is manufactured using high-quality raw materials sourced from reputable suppliers, ensuring its purity and reliability.

          02/16/2017

            The protein product is carefully packaged using appropriate storage conditions, such as freeze-drying or cold chain shipping, to maintain its stability and integrity.

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