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Recombinant Human ADAMTSL4 protein, GST-tagged

Cat.No. : ADAMTSL4-32H
Product Overview : Recombinant Human ADAMTSL4(1 a.a. - 424 a.a.) fused with GST tag at N-terminal was expressed in Wheat Germ.
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  • Gene Information
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Description : This gene is a member of ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs)-like gene family and encodes a protein with seven thrombospondin type 1 repeats. The thrombospondin type 1 repeat domain is found in many proteins with diverse biological functions including cellular adhesion, angiogenesis, and patterning of the developing nervous system. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Source : Wheat Germ
Species : Human
Tag : GST
Form : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Molecular Mass : 72.2 kDa
AA Sequence : MPAPPHPRTPLGSPAAYWKRVGHSA CSASCGKGVWRPIFLCISRESGEEL DERSCAAGARPPASPEPCHGTPCPP YWEAGEWTSCSRSCGPGTQHRQLQC RQEFGGGGSSVPPERCGHLPRPNIT QSCQLRLCGHWEVGSPWSQCSVRCG RGQRSRQVRCVGNNGDEVSEQECAS GPPQPPSREACDMGPCTTAWFHSDW SSKCSAECGTGIQRRSVVCLGSGAA LGPGQGEAGAGTGQSCPTGSRPPDM RACSLGPCERTWRWYTGPWGECSSE CGSGTQRRDIICVSKLGTEFNVTSP SNCSHLPRPPALQPCQGQACQDRWF STPWSPCSRSCQGGTQTREVQCLST NQTLSTRCPPQLRPSRKRPCNSQPC SQRPDDQCKDSSPHCPLVVQARLCV YPYYTATCCRSCAHVLERSPQDPS
Applications : Enzyme-linked Immunoabsorbent Assay; Western Blot (Recombinant protein); Antibody Production; Protein Array
Notes : Best use within three months from the date of receipt of this protein.
Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
Gene Name : ADAMTSL4 ADAMTS-like 4 [ Homo sapiens ]
Official Symbol : ADAMTSL4
Synonyms : ADAMTSL4; ADAMTS-like 4; thrombospondin repeat containing 1 , TSRC1; ADAMTS-like protein 4; DKFZP434K1772; ADAMTSL-4; thrombospondin repeat containing 1; thrombospondin repeat-containing protein 1; TSRC1;
Gene ID : 54507
mRNA Refseq : NM_019032
Protein Refseq : NP_061905
MIM : 610113
UniProt ID : Q6UY14
Chromosome Location : 1q21.2
Function : metalloendopeptidase activity; peptidase activity; protease binding; protein binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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How does ADAMTSL4 protein interact with other proteins in the body? 07/29/2022

ADAMTSL4 protein interacts with various extracellular matrix components, including fibrillin-1, collagen, and elastin. It has also been shown to interact with growth factors and receptors, such as TGF-β receptors.

Are there any current clinical trials testing the use of ADAMTSL4 protein as a therapy? 09/01/2021

As of now, there are no clinical trials testing the use of ADAMTSL4 protein as a therapy. However, preclinical studies are ongoing to determine its potential for use as a therapeutic target in various conditions.

Can ADAMTSL4 protein be used to treat Marfan syndrome? 05/25/2021

While ADAMTSL4 protein is not directly involved in Marfan syndrome, it has been shown to interact with fibrillin-1, a protein that is mutated in Marfan syndrome. Therefore, targeting ADAMTSL4 protein could potentially help to restore normal extracellular matrix function and prevent or slow down disease progression in Marfan syndrome.

Can ADAMTSL4 protein be used to improve wound healing? 04/23/2021

While ADAMTSL4 has been shown to play a role in tissue repair, there is no evidence to suggest that it could be used to directly improve wound healing. However, further research may identify potential therapeutic targets.

Are there any drugs currently available that target ADAMTSL4 protein? 04/13/2021

At present, there are no drugs that specifically target ADAMTSL4 protein. However, drugs that target other components of the extracellular matrix may indirectly affect ADAMTSL4 function.

How is ADAMTSL4 protein produced in the body? 06/24/2020

ADAMTSL4 protein is produced in various tissues throughout the body, including the retina, skin, and connective tissues. Its production is regulated by various factors, including growth factors and extracellular matrix components.

What are the effects of mutations in the ADAMTSL4 gene? 12/15/2019

Mutations in the ADAMTSL4 gene have been associated with various disorders, including ectopia lentis (dislocated lens), isolated familial horizontal strabismus (eye misalignment), and various connective tissue disorders. The precise effects of these mutations on ADAMTSL4 protein function are not yet fully understood.

Is ADAMTSL4 protein involved in the development of connective tissue disorders? 04/28/2019

There is limited evidence to suggest that ADAMTSL4 protein may be involved in the development of connective tissue disorders such as Ehlers-Danlos syndrome and Loeys-Dietz syndrome. However, further research is needed to determine its precise role and potential therapeutic applications.

What other conditions could ADAMTSL4 protein potentially be used to treat? 11/12/2018

ADAMTSL4 protein could potentially be used to treat various connective tissue disorders, as well as craniofacial abnormalities and other conditions that involve abnormal extracellular matrix function.

Is ADAMTSL4 protein being studied for retinal diseases? 06/11/2018

Yes, ADAMTSL4 protein is being studied for its potential role in retinal diseases such as age-related macular degeneration (AMD) and retinal detachment. It has been shown to interact with various components of the extracellular matrix in the retina, and may play a role in maintaining retinal integrity.

Can ADAMTSL4 protein be used to treat Marfan syndrome? 06/29/2017

ADAMTSL4 protein is being studied as a potential therapeutic target for Marfan syndrome, as it has been shown to interact with fibrillin-1, a protein that is affected in Marfan syndrome. However, further research is needed to determine its clinical applications.

Is ADAMTSL4 protein currently used as a therapy for any condition? 05/13/2016

Currently, ADAMTSL4 protein is not used as a therapy for any condition. However, it has shown potential as a therapeutic target in various conditions, including retinal diseases, craniofacial abnormalities, and Marfan syndrome, and research is ongoing to determine its potential clinical applications.

Can ADAMTSL4 protein be used to treat craniofacial abnormalities? 04/25/2016

ADAMTSL4 protein has been shown to play a role in embryonic development, and may contribute to the development of craniofacial abnormalities. However, its potential therapeutic applications in this context are not yet clear.

What are the therapeutic applications of ADAMTSL4 protein? 01/18/2016

ADAMTSL4 protein has been studied for its potential therapeutic applications in conditions such as retinal diseases, craniofacial abnormalities, Marfan syndrome, and various connective tissue disorders.

How could ADAMTSL4 protein be used in the treatment of retinal diseases? 08/19/2015

ADAMTSL4 protein is involved in the formation and maintenance of the extracellular matrix in the retina, and mutations in the ADAMTSL4 gene have been associated with various retinal disorders, including early-onset macular degeneration and retinal detachment. Therefore, ADAMTSL4 protein could potentially be used in the treatment of these conditions by restoring normal extracellular matrix function and preventing or slowing down disease progression.

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