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Recombinant Human ADARB1 Protein, MYC/DDK-tagged

Cat.No. : ADARB1-1147H
Product Overview : Recombinant human ADARB1 protein, fused to MYC/DDK tag at C-terminus, was expressed in HEK293.
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Description : This gene encodes the enzyme responsible for pre-mRNA editing of the glutamate receptor subunit B by site-specific deamination of adenosines. Studies in rat found that this enzyme acted on its own pre-mRNA molecules to convert an AA dinucleotide to an AI dinucleotide which resulted in a new splice site. Alternative splicing of this gene results in several transcript variants, some of which have been characterized by the presence or absence of an ALU cassette insert and a short or long C-terminal region. [provided by RefSeq, Jul 2008]
Source : HEK293
Species : Human
Tag : MYC/DDK
Form : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
Molecular Mass : 76.5 kDa
Purity : >50 ug/mL as determined by microplate BCA method
Concentration : >50 ug/mL as determined by microplate BCA method
Gene Name : ADARB1 adenosine deaminase, RNA-specific, B1 [ Homo sapiens ]
Official Symbol : ADARB1
Synonyms : ADAR2; DRABA2; DRADA2; RED1
Gene ID : 104
mRNA Refseq : NM_001112
Protein Refseq : NP_001103
MIM : 601218
UniProt ID : P78563

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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How could ADARB1 protein be used in the treatment of cancer? 06/02/2022

ADARB1 is involved in the editing of pre-mRNA transcripts of several oncogenes and tumor suppressor genes that are known to play a role in cancer pathogenesis. By targeting ADARB1, it may be possible to alter the expression and function of these factors, leading to potential therapeutic benefits for cancer patients.

What are the ethical implications of using ADARB1 protein in gene editing? 09/26/2021

The use of ADARB1 in gene editing raises ethical concerns around the potential for unintended or unpredictable consequences. It raises questions about the safety, efficacy, and ethical implications of modifying genes and potential implications for future generations. Therefore, researchers should carefully consider the ethical implications of using ADARB1 gene editing techniques.

How can ADARB1 protein help in cancer research? 04/27/2021

ADARB1 has been found to regulate tumor growth and metastasis in different types of cancer. Researchers are studying the role of ADARB1 in different cancer types and its potential as a therapeutic target. ADARB1 can be used to modify RNA molecules that are important for cancer progression.

What are the limitations to the use of ADARB1 protein in gene editing or gene therapy? 12/31/2020

The use of ADARB1 protein in gene editing and gene therapy is still in the experimental stages. While promising, additional research is needed to fully evaluate the safety and effectiveness of these approaches. Delivery of ADARB1 protein, as well as the accurate targeting of RNA editing sites, remains a challenge. Furthermore, off-target effects may still occur, potentially leading to unintended and harmful outcomes.

Are there any current drugs or therapies that target ADARB1 protein? 05/04/2020

Currently, there are no FDA-approved drugs or therapies that specifically target ADARB1 protein. However, research is ongoing to develop small molecule inhibitors and other compounds that can modulate ADARB1 activity, with the aim of developing new treatments for neurological disorders and cancer.

What are the potential side effects of targeting ADARB1 protein? 03/24/2020

The potential side effects of targeting ADARB1 protein are unknown at this time, as research in this area is still in its early stages. However, there is a risk that targeting ADARB1 could lead to unintended changes in gene expression or RNA editing, which could have negative consequences for cells or tissues. Careful monitoring and evaluation of potential side effects will be necessary as this area of research progresses.

What is the role of ADARB1 protein in RNA editing and alternative splicing? 01/31/2020

ADARB1 protein is involved in both RNA editing and alternative splicing, which are two mechanisms for modifying gene expression. Specifically, ADARB1 catalyzes the deamination of adenosine (A) to inosine (I) in RNA, which can alter the sequence and structure of RNA transcripts. This can affect alternative splicing, which is the process by which different exons are included or excluded from a mature mRNA molecule. By regulating RNA editing and alternative splicing, ADARB1 plays an important role in controlling gene expression and protein function.

How could ADARB1 protein be used in the treatment of neurological disorders? 09/05/2018

ADARB1 protein is important in the regulation of neurotransmitter receptors and ion channels, which play a vital role in the proper functioning of the nervous system. By targeting ADARB1, it may be possible to regulate the expression of genes involved in neurotransmitter signaling pathways, leading to potential therapeutic benefits for neurological disorders.

How can ADARB1 protein be delivered to cells or tissues for therapeutic purposes? 01/19/2018

ADARB1 protein can be delivered to cells or tissues in different ways such as by viral vectors, nanoparticles, lipid-based delivery systems, or direct injection into the targeted area. Researchers are exploring ways to develop efficient and specific delivery systems for ADARB1 protein.

What are some potential applications of ADARB1 protein? 10/24/2017

ADARB1 protein has potential applications in neurological disorders, such as epilepsy, depression, and multiple sclerosis. It is also being studied as a potential therapeutic target for the treatment of some cancers, including glioblastoma and colon cancer.

Can ADARB1 protein be used in gene editing? 06/03/2017

Yes, ADARB1 protein can be used in RNA editing for gene therapy applications. ADARB1 can target specific RNA sequences and modify them through deamination. By modifying RNA, ADARB1 can create or repair RNA molecules to treat genetic disorders caused by mutations in RNA sequences.

How is ADARB1 protein being developed as a therapeutic target? 03/23/2016

ADARB1 is being developed as a therapeutic target for various diseases and disorders, such as neurodegenerative diseases. Researchers are exploring ways to modify the activity of the ADARB1 protein through small molecules, RNA interference, and gene therapy. The goal is to increase or decrease ADARB1 activity as needed to treat or prevent the disease.

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