Recombinant Human AEN Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: AEN-759H
• Product Overview: AEN MS Standard C13 and N15-labeled recombinant protein (NP_073604) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: Exonuclease with activity against single- and double-stranded DNA and RNA. Mediates p53-induced apoptosis. When induced by p53 following DNA damage, digests double-stranded DNA to form single-stranded DNA and amplifies DNA damage signals, leading to enhancement of apoptosis.
• Source: HEK293
• Species: Human
• Tag: Myc/DDK
• Molecular Mass: 36.4 kDa
• AA Sequence: MVPREAPESAQCLCPSLTIPNAKDV LRKRHKRRSRQHQRFMARKALLQEQ GLLSMPPEPGSSPLPTPFGAATATE AASSGKQCLRAGSGSAPCSRRPAPG KASGPLPSKCVAIDCEMVGTGPRGR VSELARCSIVSYHGDVLYDKYIRPE MPIADYRTRWSGITRQHMRKAVPFQ VAQKEILKLLKGKVVVGHALHNDFQ ALKYVHPRSQTRDTTYVPNFLSEPG LHTRARVSLKDLALQLLHKKIQVGQ HGHSSVEDATTAMELYRLVEVQWEQ QEARSLWTCPEDREPDSSTDMEQYM EDQYWPDDLAHGSRGGAREAQDRRN TRTRPLEQKLISEEDLAANDILDYK DDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: AEN apoptosis enhancing nuclease [ Homo sapiens (human) ]
• Official Symbol: AEN
• Synonyms: AEN; apoptosis enhancing nuclease; interferon stimulated exonuclease gene 20kDa like 1, ISG20L1; apoptosis-enhancing nuclease; FLJ12484; FLJ12562; interferon-stimulated 20 kDa exonuclease-like 1; interferon stimulated exonuclease gene 20kDa-like 1; ISG20L1; pp12744
• Gene ID: 64782
• mRNA Refseq: NM_022767
• Protein Refseq: NP_073604
• MIM: 610177
• UniProt ID: Q8WTP8