Recombinant Human ALS2, His-tagged
Cat.No. : | ALS2-9600H |
Product Overview : | Recombinant Human ALS2 protein, fused to His-tag, was expressed in E.coli and purified by Ni-sepharose. |
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Description : | The protein encoded by this gene contains an ATS1/RCC1-like domain, a RhoGEF domain, and a vacuolar protein sorting 9 (VPS9) domain, all of which are guanine-nucleotide exchange factors that activate members of the Ras superfamily of GTPases. The protein functions as a guanine nucleotide exchange factor for the small GTPase RAB5. The protein localizes with RAB5 on early endosomal compartments, and functions as a modulator for endosomal dynamics. Mutations in this gene result in several forms of juvenile lateral sclerosis and infantile-onset ascending spastic paralysis. Multiple transcript variants encoding different isoforms have been found for this gene. |
Source : | E.coli |
Species : | Human |
Tag : | His |
Protein length : | N-term-304a.a. |
Storage : | The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles. |
Storage Buffer : | 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol. |
Publication : |
Fabrication, assessment, and optimization of alendronate sodium nanoemulsion-based injectable in-situ gel formulation for management of osteoporosis (2022)
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Gene Name : | ALS2 amyotrophic lateral sclerosis 2 (juvenile) [ Homo sapiens ] |
Official Symbol : | ALS2 |
Synonyms : | ALS2; amyotrophic lateral sclerosis 2 (juvenile); ALS2CR6, amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 6; alsin; amyotrophic lateral sclerosis 2 protein; amyotrophic lateral sclerosis 2 chromosomal region candidate gene 6 protein; ALSJ; PLSJ; IAHSP; ALS2CR6; FLJ31851; KIAA1563; MGC87187; |
Gene ID : | 57679 |
mRNA Refseq : | NM_001135745 |
Protein Refseq : | NP_001129217 |
MIM : | 606352 |
UniProt ID : | Q96Q42 |
Chromosome Location : | 2q33-q35 |
Pathway : | Amyotrophic lateral sclerosis (ALS), organism-specific biosystem; Amyotrophic lateral sclerosis (ALS), conserved biosystem; |
Function : | Rab GTPase binding; Rab GTPase binding; Rab guanyl-nucleotide exchange factor activity; Rac guanyl-nucleotide exchange factor activity; Ran guanyl-nucleotide exchange factor activity; contributes_to guanyl-nucleotide exchange factor activity; protein homo |
Products Types
◆ Recombinant Protein | ||
ALS2-491M | Recombinant Mouse ALS2 Protein, His (Fc)-Avi-tagged | +Inquiry |
ALS2-298R | Recombinant Rat ALS2 Protein, His (Fc)-Avi-tagged | +Inquiry |
ALS2-497H | Recombinant Human ALS2 Protein, GST-tagged | +Inquiry |
ALS2-1577M | Recombinant Mouse ALS2 Protein | +Inquiry |
ALS2-642R | Recombinant Rat ALS2 Protein | +Inquiry |
◆ Lysates | ||
ALS2-66HCL | Recombinant Human ALS2 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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